Predictors of Incident Diabetes in Two Populations: Framingham Heart Study and Hispanic Community Health Study / Study of Latinos

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Citation

Kaplan, Robert C.; Song, Rebecca J.; Lin, Juan; Xanthakis, Vanessa; Hua, Simin; Chernofsky, Ariel; Evenson, Kelly R.; Walker, Maura E.; Cuthbertson, Carmen C.; & Murabito, Joanne M., et al. (2022). Predictors of Incident Diabetes in Two Populations: Framingham Heart Study and Hispanic Community Health Study / Study of Latinos. BMC Public Health, 22(1), 1053. PMCID: PMC9137165

Abstract

BACKGROUND: Non-genetic factors contribute to differences in diabetes risk across race/ethnic and socioeconomic groups, which raises the question of whether effects of predictors of diabetes are similar across populations. We studied diabetes incidence in the primarily non-Hispanic White Framingham Heart Study (FHS, N = 4066) and the urban, largely immigrant Hispanic Community Health Study/Study of Latinos (HCHS/SOL, N = 6891).
METHODS: Clinical, behavioral, and socioeconomic characteristics were collected at in-person examinations followed by seven-day accelerometry. Among individuals without diabetes, Cox proportional hazards regression models (both age- and sex-adjusted, and then multivariable-adjusted for all candidate predictors) identified predictors of incident diabetes over a decade of follow-up, defined using clinical history or laboratory assessments.
RESULTS: Four independent predictors were shared between FHS and HCHS/SOL. In each cohort, the multivariable-adjusted hazard of diabetes increased by approximately 50% for every ten-year increment of age and every five-unit increment of body mass index (BMI), and was 50-70% higher among hypertensive than among non-hypertensive individuals (all P < 0.01). Compared with full-time employment status, the multivariable-adjusted hazard ratio (HR) and 95% confidence interval (CI) for part-time employment was 0.61 (0.37,1.00) in FHS and 0.62 (0.41,0.95) in HCHS/SOL. Moderate-to-vigorous physical activity (MVPA) was an additional predictor in common observed in age- and sex-adjusted models, which did not persist after adjustment for other covariates (compared with MVPA 

URL

http://dx.doi.org/10.1186/s12889-022-13463-8

Reference Type

Journal Article

Year Published

2022

Journal Title

BMC Public Health

Author(s)

Kaplan, Robert C.
Song, Rebecca J.
Lin, Juan
Xanthakis, Vanessa
Hua, Simin
Chernofsky, Ariel
Evenson, Kelly R.
Walker, Maura E.
Cuthbertson, Carmen C.
Murabito, Joanne M.
Cordero, Christina
Daviglus, Martha L.
Perreira, Krista M.
Gellman, Marc D.
Sotres-Alvarez, Daniela T.
Vasan, Ramachandran S.
Xue, Xiaonan
Spartano, Nicole L.
Mossavar-Rahmani, Yasmin

Article Type

Regular

PMCID

PMC9137165

Data Set/Study

Framingham Heart Study (FHS)
Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Continent/Country

United States of America

State

Nonspecific

Race/Ethnicity

Hispanic/Latinx
White

ORCiD

Perreira - 0000-0003-2906-0261