Citation
Henderson, Heather I.; Napravnik, Sonia; Kosorok, Michael R.; Gower, Emily W.; Kinlaw, Alan C.; Aiello, Allison E.; Williams, Billy; Wohl, David A.; & van Duin, David (2022). Predicting Risk of Multidrug-Resistant Enterobacterales Infections among People with HIV. Open Forum Infectious Diseases, 9(10), ofac487. PMCID: PMC9547514Abstract
BACKGROUND: Medically vulnerable individuals are at increased risk of acquiring multidrug-resistant Enterobacterales (MDR-E) infections. People with HIV (PWH) experience a greater burden of comorbidities and may be more susceptible to MDR-E due to HIV-specific factors.METHODS: We performed an observational study of PWH participating in an HIV clinical cohort and engaged in care at a tertiary care center in the Southeastern United States from 2000 to 2018. We evaluated demographic and clinical predictors of MDR-E by estimating prevalence ratios (PRs) and employing machine learning classification algorithms. In addition, we created a predictive model to estimate risk of MDR-E among PWH using a machine learning approach.
RESULTS: Among 4734 study participants, MDR-E was isolated from 1.6% (95% CI, 1.2%-2.1%). In unadjusted analyses, MDR-E was strongly associated with nadir CD4 cell count
URL
http://dx.doi.org/10.1093/ofid/ofac487Reference Type
Journal ArticleYear Published
2022Journal Title
Open Forum Infectious DiseasesAuthor(s)
Henderson, Heather I.Napravnik, Sonia
Kosorok, Michael R.
Gower, Emily W.
Kinlaw, Alan C.
Aiello, Allison E.
Williams, Billy
Wohl, David A.
van Duin, David