Citation
Wang, Yiqing; Wang, Huijun; Howard, Annie Green; Meyer, Katie A.; Tsilimigras, Matthew C. B.; Avery, Christy L.; Sha, Wei; Sun, Shan; Zhang, Jiguo; & Su, Chang, et al. (2020). Circulating Short-Chain Fatty Acids Are Positively Associated with Adiposity Measures in Chinese Adults. Nutrients, 12(7), 2127. PMCID: PMC7400849Abstract
Epidemiological studies suggest a positive association between obesity and fecal short-chain fatty acids (SCFAs) produced by microbial fermentation of dietary carbohydrates, while animal models suggest increased energy harvest through colonic SCFA production in obesity. However, there is a lack of human population-based studies with dietary intake data, plasma SCFAs, gut microbial, and anthropometric data. In 490 Chinese adults aged 30–68 years, we examined the associations between key plasma SCFAs (butyrate/isobutyrate, isovalerate, and valerate measured by non-targeted plasma metabolomics) with body mass index (BMI) using multivariable-adjusted linear regression. We then assessed whether overweight (BMIURL
http://dx.doi.org/10.3390/nu12072127Reference Type
Journal ArticleYear Published
2020Journal Title
NutrientsAuthor(s)
Wang, YiqingWang, Huijun
Howard, Annie Green
Meyer, Katie A.
Tsilimigras, Matthew C. B.
Avery, Christy L.
Sha, Wei
Sun, Shan
Zhang, Jiguo
Su, Chang
Wang, Zhihong
Zhang, Bing
Fodor, Anthony A.
Gordon-Larsen, Penny