Neighborhood Environment, Social Cohesion, and Epigenetic Aging

Citation

Martin, Chantel L.; Ward-Caviness, Cavin K.; Dhingra, Radhika; Zikry, Tarek M.; Galea, Sandro; Wildman, Derek E.; Koenen, Karestan C.; Uddin, Monica; & Aiello, Allison E. (2021). Neighborhood Environment, Social Cohesion, and Epigenetic Aging. Aging, 13(6), 7883-7899. PMCID: PMC8034890

Abstract

Living in adverse neighborhood environments has been linked to risk of aging-related diseases and mortality; however, the biological mechanisms explaining this observation remain poorly understood. DNA methylation (DNAm), a proposed mechanism and biomarker of biological aging responsive to environmental stressors, offers promising insight into potential molecular pathways. We examined associations between three neighborhood social environment measures (poverty, quality, and social cohesion) and three epigenetic clocks (Horvath, Hannum, and PhenoAge) using data from the Detroit Neighborhood Health Study (n=158). Using linear regression models, we evaluated associations in the total sample and stratified by sex and social cohesion. Neighborhood quality was associated with accelerated DNAm aging for Horvath age acceleration (

URL

http://dx.doi.org/10.18632/aging.202814

Reference Type

Journal Article

Year Published

2021

Journal Title

Aging

Author(s)

Martin, Chantel L.
Ward-Caviness, Cavin K.
Dhingra, Radhika
Zikry, Tarek M.
Galea, Sandro
Wildman, Derek E.
Koenen, Karestan C.
Uddin, Monica
Aiello, Allison E.

Article Type

Regular

PMCID

PMC8034890

Data Set/Study

Detroit Neighborhood Health Study (DNHS)

Continent/Country

United States of America

State

Michigan

ORCiD

Martin, C. - 0000-0003-1907-0810
Aiello - 0000-0001-7029-2537