Immune Function, Cortisol, and Cognitive Decline & Dementia in an Aging Latino Population

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Citation

Stebbins, Rebecca C.; Edwards, Jessie K.; Plassman, Brenda L.; Yang, Yang Claire; Noppert, Grace A.; Haan, Mary N.; & Aiello, Allison E. (2021). Immune Function, Cortisol, and Cognitive Decline & Dementia in an Aging Latino Population. Psychoneuroendocrinology, 133, 105414. PMCID: PMC8600484

Abstract

BACKGROUND: The etiology of dementias and cognitive decline remain largely unknown. It is widely accepted that inflammation in the central nervous system plays a critical role in the pathogenesis of dementia. However, less is known about the role of the peripheral immune system and interactions with cortisol, though evidence suggests that these, too, may play a role.
METHODS: Using data from 1337 participants aged 60+ years from the Sacramento Area Latino Study of Aging (observational cohort) we investigated variation in trajectories of cognitive decline by pathogen IgG and cytokine levels. Linear mixed effects models were used to examine the association between baseline Interleukin (IL)-6, C-reactive protein, tumor necrosis factor (TNF)-

URL

http://dx.doi.org/10.1016/j.psyneuen.2021.105414

Reference Type

Journal Article

Year Published

2021

Journal Title

Psychoneuroendocrinology

Author(s)

Stebbins, Rebecca C.
Edwards, Jessie K.
Plassman, Brenda L.
Yang, Yang Claire
Noppert, Grace A.
Haan, Mary N.
Aiello, Allison E.

Article Type

Regular

PMCID

PMC8600484

Data Set/Study

Sacramento Area Latino Study on Aging (SALSA)

Continent/Country

United States of America

State

California

Race/Ethnicity

Hispanic/Latinx

ORCiD

Noppert - 0000-0002-2040-960x
Yang - 0000-0001-7279-1479
Aiello - 0000-0001-7029-2537
Edwards, J -0000-0002-1741-335X