Do Adverse Childhood Experiences and Genetic Obesity Risk Interact in Relation to Body Mass Index in Young Adulthood? Findings from the National Longitudinal Study of Adolescent to Adult Health

Download as .RIS

Citation

Inoue, Yosuke; Graff, Mariaelisa; Howard, Annie Green; Highland, Heather M.; Young, Kristin L.; Harris, Kathleen Mullan; North, Kari E.; Li, Yun; Duan, Qing; & Gordon-Larsen, Penny (2022). Do Adverse Childhood Experiences and Genetic Obesity Risk Interact in Relation to Body Mass Index in Young Adulthood? Findings from the National Longitudinal Study of Adolescent to Adult Health. Pediatric Obesity, 17(6), e12885. PMCID: PMC9098659

Abstract

BACKGROUND: Few studies have focused on the role of adverse childhood experiences (ACEs) in relation to genetic susceptibility to obesity.
OBJECTIVE: We aimed to examine the interaction between the presence of ACEs (i.e., physical, psychological and sexual abuse) before the age of 18 and BMI polygenic score.
METHODS: Data came from the National Longitudinal Study of Adolescent to Adult Health (Add Health) Wave IV (2007/2008) where saliva samples were collected for DNA genotyping and information on BMI and ACEs were obtained from 5854 European American (EA), 2073 African American (AA) and 1448 Hispanic American (HA) participants aged 24 to 32 years old. Polygenic scores were calculated as the sum of the number of risk alleles of BMI-related SNPs which were weighted by effect size. A race/ethnicity-stratified mixed-effects linear regression model was used to test for differential association between BMI polygenic score and BMI by the presence of ACEs.
RESULTS: We did not find any evidence of significant interaction between ACEs and polygenic score in relation to BMI among EA (p = 0.289), AA (p = 0.618) or HA (p = 0.870). In main effects models, polygenic score was positively associated with BMI in all race/ethnic groups, yet the presence of ACEs was associated with increased BMI only among EA.
CONCLUSION: We did not find any evidence that ACEs exacerbate genetic predisposition to increased BMI in early adulthood.

URL

http://dx.doi.org/10.1111/ijpo.12885

Reference Type

Journal Article

Year Published

2022

Journal Title

Pediatric Obesity

Author(s)

Inoue, Yosuke
Graff, Mariaelisa
Howard, Annie Green
Highland, Heather M.
Young, Kristin L.
Harris, Kathleen Mullan
North, Kari E.
Li, Yun
Duan, Qing
Gordon-Larsen, Penny

Article Type

Regular

PMCID

PMC9098659

Data Set/Study

National Longitudinal Study of Adolescent to Adult Health (Add Health)

Continent/Country

United States of America

State

Nonspecific

Race/Ethnicity

African-American
Hispanic/Latinx
White

ORCiD

Gordon-Larsen - 0000-0001-5322-4188
Graff - 0000-0001-6380-1735
Harris, KM - 0000-0001-9757-1026
Howard, AG - 0000-0003-0837-8166
Highland - 000-0002-3583-8239