Citation
Preudhomme, Liana K.; Gellman, Marc D.; Franceschini, Nora; Perreira, Krista M.; Fernández-Rhodes, Lindsay; Gallo, Linda C.; Isasi, Carmen R.; Smoller, Sylvia; Castañeda, Sheila F.; & Daviglus, Martha L., et al. (2022). Genetic and Stress Influences on the Prevalence of Hypertension among Hispanics/Latinos in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Blood Pressure, 31(1), 155-163.Abstract
PURPOSE: The current study examined the effects of chronic stress and a genetic risk score on the presence of hypertension and elevated systolic blood pressure and diastolic blood pressure among Hispanics/Latinos in the target population of Hispanic Community Health Study/Study of Latinos.MATERIALS AND METHODS: Of the participants (N = 11,623) assessed during two clinic visits (Visit 1 2008-2013 & Visit 2 2014-2018), we analysed data from 7,429 adults (50.4% female), aged 18-74, who were genotyped and responded to chronic stress questionnaires. We calculated an unweighted genetic risk score using blood pressure increasing single nucleotide polymorphisms (SNPs) found to be generalisable to Hispanics/Latinos (10 SNPs). Linear and logistic regression models were used to estimate associations between chronic stress and genetic risk score and their interaction, with prevalent Visit 2 SBP or DBP, and hypertension, respectively. Models accounted for sampling weights, stratification, and cluster design.
RESULTS: Chronic stress (adjusted OR = 1.18, 95%CI:1.15,1.22) and hypertension genetic risk score (adjusted OR = 1.04, 95%CI:1.01,1.07) were significantly associated with prevalent hypertension, but there was no significant interaction between the chronic stress and genetic risk score on hypertension (p = .49). genetic risk score (b = .32, 95%CI:.08, .55, R(2) = .02) and chronic stress (b = .45, 95%CI:.19, .72, R(2) = .11) were related to DBP, with no significant interaction (p = .62). Genetic risk score (b = .42, 95%CI:.08, .76, R(2) = .01) and chronic stress (b = .80, 95%CI:.34,1.26, R(2) = .11) were also related to SBP, with no significant interaction (p = .51).
CONCLUSION: Results demonstrate the utility of a genetic risk score for blood pressure and are consistent with literature suggesting chronic stress has a strong, direct association with elevated blood pressure among U.S. Hispanics/Latinos.
URL
http://dx.doi.org/10.1080/08037051.2022.2091977Reference Type
Journal ArticleYear Published
2022Journal Title
Blood PressureAuthor(s)
Preudhomme, Liana K.Gellman, Marc D.
Franceschini, Nora
Perreira, Krista M.
Fernández-Rhodes, Lindsay
Gallo, Linda C.
Isasi, Carmen R.
Smoller, Sylvia
Castañeda, Sheila F.
Daviglus, Martha L.
Hutten, Christina
Cooper, Richard S.
Cai, Jianwen
Schneiderman, Neil
Llabre, Maria M.