Citation
Noppert, Grace A.; Stebbins, Rebecca C.; Dowd, Jennifer Beam; & Aiello, Allison E. (2023). Socioeconomic and Race/Ethnic Differences in Immunosenescence: Evidence from the Health and Retirement Study. Brain, Behavior, and Immunity, 107, 361-368. PMCID: PMC9636606Abstract
BACKGROUND: The COVID-19 pandemic has highlighted the urgent need to understand variation in immunosenescence at the population-level. Thus far, population patterns of immunosenescence have not well described.METHODS: We characterized measures of immunosenescence from the 2016 Venous Blood Study from the nationally representative U.S Health and Retirement Study (HRS) of individuals ages 50 years and older.
RESULTS: Median values of the CD8+:CD4+, EMRA:Naïve CD4+ and EMRA:Naïve CD8+ ratios were higher among older participants and were lower in those with additional educational attainment. Generally, minoritized race and ethnic groups had immune markers suggestive of a more aged immune profile: Hispanics had a CD8+:CD4+ median value of 0.37 (95 % CI: 0.35, 0.39) compared to 0.30 in non-Hispanic Whites (95 % CI: 0.29, 0.31). Non-Hispanic Blacks had the highest median value of the EMRA:Naïve CD4+ ratio (0.08; 95 % CI: 0.07, 0.09) compared to non-Hispanic Whites (0.03; 95 % CI: 0.028, 0.033). In regression analyses, race/ethnicity and education were associated with large differences in the immune ratio measures after adjustment for age and sex.
CONCLUSIONS: Lower educational attainment and minoritized racial ethnic status were associated with higher levels of immunosenescence. This population variation may have important implications for both risk of age-related disease and vulnerability to emerging pathogens (e.g., SARS-CoV-2).
URL
http://dx.doi.org/10.1016/j.bbi.2022.10.019Reference Type
Journal ArticleYear Published
2023Journal Title
Brain, Behavior, and ImmunityAuthor(s)
Noppert, Grace A.Stebbins, Rebecca C.
Dowd, Jennifer Beam
Aiello, Allison E.
Article Type
RegularPMCID
PMC9636606Data Set/Study
Health and Retirement Study (HRS)Continent/Country
United States of AmericaState
NonspecificRace/Ethnicity
BlackWhite
Hispanic