Citation
Cortés, Yamnia I.; Cai, Jianwen; Daviglus, Martha; Gallo, Linda C.; Lamar, Melissa; Isasi, Carmen R.; & Perreira, Krista M. (2023). Reproductive Period Duration and Cognitive Function in Postmenopausal Latina Women in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Maturitas, 174, 23-29.Abstract
OBJECTIVES: A shorter reproductive period, a marker of estrogen exposure, has been related to cognitive impairment among older (>65 years) non-Hispanic White women. We explored whether reproductive period duration, age at menarche, and age at menopause are related to cognitive function among postmenopausal Hispanic/Latina women.METHODS: This cross-sectional analysis used baseline (Visit 1: 2008-2011) data from 3630 postmenopausal women in the Hispanic Community Health Study/Study of Latinos. Reproductive period duration, age at menarche, and age at menopause were assessed by self-report. Cognitive function variables included global cognition, verbal learning, memory, verbal fluency, and processing speed. Associations between each reproductive event and cognitive function were examined using multivariable linear and logistic regression analyses accounting for the complex survey design of the study and adjusting for socio-demographics, parity, and cardiovascular risk factors. We assessed whether associations differed by type of menopause (natural versus surgical) and hormone therapy use.
RESULTS: The study population was on average aged 59 years, with a mean reproductive period duration of 35 years. Older age at menopause and a longer reproductive period were related to higher verbal learning (
URL
http://dx.doi.org/10.1016/j.maturitas.2023.04.270Reference Type
Journal ArticleYear Published
2023Journal Title
MaturitasAuthor(s)
Cortés, Yamnia I.Cai, Jianwen
Daviglus, Martha
Gallo, Linda C.
Lamar, Melissa
Isasi, Carmen R.
Perreira, Krista M.