Citation
Saraiya, Veeral; Bradshaw, Patrick T.; Meyer, Katie A.; Lund, Jennifer L.; Slade, Gary D.; & Olshan, Andrew F. (2024). The Association between the Mediterranean Diet Score and Death from Cancer of the Head and Neck. Cancer Causes & Control, 35(1), 77-92.Abstract
PURPOSE: The association between diet quality, captured by the Mediterranean Diet Score (MDS), and mortality was studied among 1184 individuals diagnosed with head and neck cancer (HNC) who reflected on the year preceding diagnosis about their usual diet using National Cancer Institute's Diet History Questionnaire (DHQ).METHODS: Intakes of nine dietary components were scored and summed to construct the MDS (sample: median = 4; range (0-9); lower MDS reflected poorer diet quality; 5-year survival probability = 0.62). Cox regression estimated 5-year hazard ratios (HR) and 95% confidence intervals (95CI) for all-cause mortality and for HNC-specific death for contrasts of MDS quintiles. Effect measure modification (EMM) by tumor features [human papillomavirus (HPV) positivity; anatomic site] and sociodemographic behavioral factors [race, body mass index (BMI), smoking, alcohol consumption] was explored.
RESULTS: The 5-year [HR (95CI); P-trend] for all-cause mortality and HNC-specific mortality for highest versus lowest MDS quintile contrasts were [0.51 (0.33, 0.80); 0.014] and [0.43 (0.22, 0.85); 0.004], respectively. A unit increase in MDS adherence resulted in a 15% reduction of the 5-year HR for HNC-specific death for tumors located at the oral cavity [HR (95CI): 0.85 (0.75, 0.96)]. Poor diet quality (MDS
URL
http://dx.doi.org/10.1007/s10552-023-01761-4Reference Type
Journal ArticleYear Published
2024Journal Title
Cancer Causes & ControlAuthor(s)
Saraiya, VeeralBradshaw, Patrick T.
Meyer, Katie A.
Lund, Jennifer L.
Slade, Gary D.
Olshan, Andrew F.
Article Type
RegularData Set/Study
Carolina Head and Neck Cancer Epidemiology (CHANCE) StudyContinent/Country
United StatesState
North CarolinaRace/Ethnicity
BlackWhite