Citation
Tasoulas, Jason; Farquhar, Douglas R.; Sheth, Siddharth; Hackman, Trevor G.; Yarbrough, Wendell G.; Agala, Chris B.; Koric, Alzina; Giraldi, Luca; Fabianova, Eleonora; & Lissowska, Jolanta, et al. (2024). Poor Oral Health Influences Head and Neck Cancer Patient Survival: An International Head and Neck Cancer Epidemiology Consortium Pooled Analysis. Journal of the National Cancer Institute, 116(1), 105-114. PMCID: PMC10777670Abstract
BACKGROUND: Poor oral health has been identified as a prognostic factor potentially affecting the survival of patients with head and neck squamous cell carcinoma. However, evidence to date supporting this association has emanated from studies based on single cohorts with small-to-modest sample sizes.METHODS: Pooled analysis of 2449 head and neck squamous cell carcinoma participants from 4 studies of the International Head and Neck Cancer Epidemiology Consortium included data on periodontal disease, tooth brushing frequency, mouthwash use, numbers of natural teeth, and dental visits over the 10 years prior to diagnosis. Multivariable generalized linear regression models were used and adjusted for age, sex, race, geographic region, tumor site, tumor-node-metastasis stage, treatment modality, education, and smoking to estimate risk ratios (RR) of associations between measures of oral health and overall survival.
RESULTS: Remaining natural teeth (10-19 teeth: RR = 0.81, 95% confidence interval [CI] = 0.69 to 0.95;
URL
http://dx.doi.org/10.1093/jnci/djad156Reference Type
Journal ArticleYear Published
2024Journal Title
Journal of the National Cancer InstituteAuthor(s)
Tasoulas, JasonFarquhar, Douglas R.
Sheth, Siddharth
Hackman, Trevor G.
Yarbrough, Wendell G.
Agala, Chris B.
Koric, Alzina
Giraldi, Luca
Fabianova, Eleonora
Lissowska, Jolanta
Świątkowska, Beata
Vilensky, Marta
W
ünsch-Filho, Victor
de Carvalho, Marcos Brasilino
López, Rossana Verónica Mendoza
Holcátová, Ivana
Serraino, Diego
Polesel, Jerry
Canova, Cristina
Richiardi, Lorenzo
Zevallos, Jose P.
Ness, Andy R.
Pring, Miranda
Thomas, Steve J.
Dudding, Tom
Lee, Yuan-Chin Amy
Hashibe, Mia
Boffetta, Paolo
Olshan, Andrew F.
Divaris, Kimon
Amelio, Antonio L.