Citation
Stephenson, Kathryn E.; Marcelin, Jasmine R.; Pettifor, Audrey E.; Janes, Holly; Brown, Elizabeth E.; Neradilek, Moni; Yen, Catherine; Andriesen, Jessica; Grunenberg, Nicole; & Espy, Nicole, et al. (2023). Efficacy of Messenger RNA–1273 Against Severe Acute Respiratory Syndrome Coronavirus 2 Acquisition in Young Adults From March to December 2021. Open Forum Infectious Diseases, 10(11), ofad511. PMCID: PMC10655942Abstract
BACKGROUND: The efficacy of messenger RNA (mRNA)–1273 against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well defined, particularly among young adults.METHODS: Adults aged 18–29 years with no known history of SARS-CoV-2 infection or prior vaccination for coronavirus disease 2019 (COVID-19) were recruited from 44 US sites from 24 March to 13 September 2021 and randomized 1:1 to immediate vaccination (receipt of 2 doses of mRNA-1273 vaccine at months 0 and 1) or the standard of care (receipt of COVID-19 vaccine). Randomized participants were followed up for SARS-CoV-2 infection measured by nasal swab testing and symptomatic COVID-19 measured by nasal swab testing plus symptom assessment and assessed for the primary efficacy outcome. A vaccine-declined observational group was also recruited from 16 June to 8 November 2021 and followed up for SARS-CoV-2 infection as specified for the randomized participants.
RESULTS: The study enrolled 1149 in the randomized arms and 311 in the vaccine-declined group and collected >122 000 nasal swab samples. Based on randomized participants, the efficacy of 2 doses of mRNA-1273 vaccine against SARS-CoV-2 infection was 52.6% (95% confidence interval,
URL
http://dx.doi.org/10.1093/ofid/ofad511Reference Type
Journal ArticleYear Published
2023Journal Title
Open Forum Infectious DiseasesAuthor(s)
Stephenson, Kathryn E.Marcelin, Jasmine R.
Pettifor, Audrey E.
Janes, Holly
Brown, Elizabeth E.
Neradilek, Moni
Yen, Catherine
Andriesen, Jessica
Grunenberg, Nicole
Espy, Nicole
Trahey, Meg
Fischer, Rebecca S. B.
DeSouza, Christopher A.
Shisler, Joanna L.
Connick, Elizabeth
Houpt, Eric R.
Chu, Helen Y.
McCulloh, Russel J.
Becker-Dreps, Sylvia I.
Vielot, Nadja A.
Kalbaugh, Corey A,
Cherabuddi, Kartik
Krueger, Karen M.
Rosenberg, Molly Sears
Greenberg, Richard N.
Joaquin, Arnel
Immergluck, Lilly C.
Corey, Lawrence
Kublin, James G.