Citation
Stickel, Ariana M.; Tarraf, Wassim; Kuwayama, Sayaka; Wu, Benson; Sundermann, Erin E.; Gallo, Linda C.; Lamar, Melissa; Daviglus, Martha; Zeng, Donglin; & Thyagarajan, Bharat, et al. (Online ahead of print). Connections between Reproductive Health and Cognitive Aging among Women Enrolled in the HCHS/SOL and SOL-INCA. Alzheimer's & Dementia.Abstract
INTRODUCTION: Reproductive health history may contribute to cognitive aging and risk for Alzheimer's disease, but this is understudied among Hispanic/Latina women.METHODS: Participants included 2126 Hispanic/Latina postmenopausal women (44 to 75 years) from the Study of Latinos-Investigation of Neurocognitive Aging. Survey linear regressions separately modeled the associations between reproductive health measures (age at menarche, history of oral contraceptive use, number of pregnancies, number of live births, age at menopause, female hormone use at Visit 1, and reproductive span) with cognitive outcomes at Visit 2 (performance, 7-year change, and mild cognitive impairment [MCI] prevalence).
RESULTS: Younger age at menarche, oral contraceptive use, lower pregnancies, lower live births, and older age at menopause were associated with better cognitive performance. Older age at menarche was protective against cognitive change. Hormone use was linked to lower MCI prevalence.
DISCUSSION: Several aspects of reproductive health appear to impact cognitive aging among Hispanic/Latina women.
URL
http://dx.doi.org/10.1002/alz.13575Reference Type
Journal ArticleYear Published
Online ahead of printJournal Title
Alzheimer's & DementiaAuthor(s)
Stickel, Ariana M.Tarraf, Wassim
Kuwayama, Sayaka
Wu, Benson
Sundermann, Erin E.
Gallo, Linda C.
Lamar, Melissa
Daviglus, Martha
Zeng, Donglin
Thyagarajan, Bharat
Isasi, Carmen R.
Lipton, Richard B.
Cordero, Christina
Perreira, Krista M.
Gonzalez, Hector M.
Banks, Sarah J.