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Diagnostic Radiation and the Risk of Multiple Myeloma (United States)


Hatcher, Juliet L.; Baris, Dalsu; Olshan, Andrew F.; Inskip, Peter D.; Savitz, David A.; Swanson, G. Marie; Pottern, Linda M.; Greenberg, Raymond S.; Schwartz, Ann G.; & Schoenberg, Janet B., et al. (2001). Diagnostic Radiation and the Risk of Multiple Myeloma (United States). Cancer Causes & Control, 12(8), 755-61.


Objective: To evaluate the relationship between cumulative lifetime exposure to diagnostic radiation and the risk of multiple myeloma using data from a large, multi-center, population-based case–control study. Methods: Study subjects included a total of 540 cases with newly diagnosed multiple myeloma and 1998 frequency-matched population controls living in three areas of the United States (Georgia, Michigan, New Jersey). Information on exposure to diagnostic X-rays was obtained by personal interview. Results: No association was found between case–control status and the total number of reported diagnostic X-rays of any type (odds ratio (OR) for 20 or more compared to less than 5 X-rays = 0.9, 95% confidence interval (95% CI) = 0.7–1.2). There was no evidence of an excess risk of multiple myeloma among individuals who reported exposure to 10 or more diagnostic X-rays that impart a relatively high radiation dose to the bone marrow, as compared to individuals reporting no such exposures (OR 0.7, 95% CI 0.4–1.3). Conclusions: These data suggest that exposure to diagnostic X-rays has a negligible impact, if any, on risk of developing multiple myeloma.


Reference Type

Journal Article

Journal Title

Cancer Causes & Control


Hatcher, Juliet L.
Baris, Dalsu
Olshan, Andrew F.
Inskip, Peter D.
Savitz, David A.
Swanson, G. Marie
Pottern, Linda M.
Greenberg, Raymond S.
Schwartz, Ann G.
Schoenberg, Janet B.
Brown, Linda Morris

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