Menu Close

Attenuation of Exposure-Response Curves in Occupational Cohort Studies at High Exposure Levels

Citation

Stayner, Leslie; Steenland, Kyle; Dosemeci, Mustafa; & Hertz-Picciotto, Irva (2003). Attenuation of Exposure-Response Curves in Occupational Cohort Studies at High Exposure Levels. Scandinavian Journal of Work, Environment and Health, 29(4), 317-324.

Abstract

Numerous occupational cohort mortality studies have observed exposure-response curves to have an increasing slope at low exposure levels that attenuates or even turns negative at high exposure levels. Examples discussed in this paper include dioxin, silica, 1,3-butadiene, cadmium, beryllium, radon daughters, diesel fumes, nickel, arsenic, and hexavalent chromium. Possible explanations for this phenomenon include (i) bias introduced by the healthy worker survivor effect, (ii) a depletion of the number of susceptible people in the population at high exposure levels, (iii) a natural limit on the relative risk for diseases with a high background rate, (iv) mismeasurement or misclassification of exposures, (v) the influence of other risk factors that vary by the level of the main exposure, and (vi) the saturation of key enzyme systems or other processes involved in the development of disease.

URL

http://dx.doi.org/10.5271/sjweh.737

Reference Type

Journal Article

Year Published

2003

Journal Title

Scandinavian Journal of Work, Environment and Health

Author(s)

Stayner, Leslie
Steenland, Kyle
Dosemeci, Mustafa
Hertz-Picciotto, Irva