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Tocolytic Treatment for the Management of Preterm Labor: A Review of the Evidence

Citation

Berkman, Nancy D.; Thorp, John M., Jr.; Lohr, Kathleen N.; Carey, Timothy S.; Hartmann, Katherine E.; Gavin, Norma I.; Hasselblad, Victor; & Idicula, Anjolie E. (2003). Tocolytic Treatment for the Management of Preterm Labor: A Review of the Evidence. American Journal of Obstetrics & Gynecology, 188(6), 1648-59.

Abstract

Objective: Preterm labor is often a prelude to early births and the significant attendant burden of infant morbidity and mortality. Treatment consists of bedrest, hydration, pharmacologic interventions, and combinations of these. We systematically reviewed the effectiveness of tocolytics to stop uterine contractions (first-line therapy) or maintain quiescence (maintenance therapy). Our objective was to evaluate the evidence on the benefits and harms of five classes of tocolytic therapy for treating uterine contractions related to preterm labor--beta-mimetics, calcium channel blockers, magnesium, nonsteroidal anti-inflammatory agents, and ethanol.

URL

http://dx.doi.org/10.1067/mob.2003.356

Reference Type

Journal Article

Journal Title

American Journal of Obstetrics & Gynecology

Author(s)

Berkman, Nancy D.
Thorp, John M., Jr.
Lohr, Kathleen N.
Carey, Timothy S.
Hartmann, Katherine E.
Gavin, Norma I.
Hasselblad, Victor
Idicula, Anjolie E.

Year Published

2003

Volume Number

188

Issue Number

6

Pages

1648-59

Reference ID

2193