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Phase I Safety & Preliminary Acceptability of Nonoxynol-9 Vaginal Pessary as a Vaginal Microbicide in Low Risk Women in Pune, India

Citation

Joshi, Smita; Joglekar, Neelam S.; Ghate, Manisha; Unni, Jyothi; Risbud, A.; Bentley, Margaret E.; Shepherd, Mary E.; Bollinger, Robert C.; & Mehendale, Sanjay M. (2003). Phase I Safety & Preliminary Acceptability of Nonoxynol-9 Vaginal Pessary as a Vaginal Microbicide in Low Risk Women in Pune, India. Indian Journal of Medical Research, 117, 152-7.

Abstract

Background & objectives: Though nonoxynol-9 (N-9) is available in India as a spermicidal pessary, data on its safety as a potential microbicide among Indian women are not available. Nonoxynol-9 containing compounds have shown anti-HIV activity in in vitro studies and protection against cervical infections. Nonoxynol-9 is being extensively evaluated as a vaginal microbicide world-wide. We assessed the safety and preliminary acceptability of nonoxynol-9 pessary as a vaginal microbicide in women at low risk for human immunodeficiency virus (HIV) infection and sexually transmitted diseases (STDs).

Reference Type

Journal Article

Journal Title

Indian Journal of Medical Research

Author(s)

Joshi, Smita
Joglekar, Neelam S.
Ghate, Manisha
Unni, Jyothi
Risbud, A.
Bentley, Margaret E.
Shepherd, Mary E.
Bollinger, Robert C.
Mehendale, Sanjay M.

Year Published

2003

Volume Number

117

Pages

152-7

Reference ID

2243