DNA Repair Polymorphisms XRCC1 and MGMT and Risk of Adult Gliomas

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Citation

Felini, Martha J.; Olshan, Andrew F.; Schroeder, Jane C.; North, Kari E.; Carozza, Susan E.; Kelsey, Karl T.; Liu, Mei; Rice, Terri; Wiencke, John K.; & Wrensch, Margaret R. (2007). DNA Repair Polymorphisms XRCC1 and MGMT and Risk of Adult Gliomas. Neuroepidemiology, 29(1-2), 55-58.

Abstract

X-ray cross complementing group 1 (XRCC1) and O6-methylguanine-DNA methyltransferase (MGMT) are pivotal repair genes focused on repairing lesions due to ionizing radiation, alkylating agents, and oxidative DNA damage, risk factors previously linked to gliomas. Using the population based San Francisco Adult Glioma study, we evaluated associations between XRCC1 Arg399Gln, MGMT Leu84Phe, and MGMT Ile143Val polymorphisms with glioma risk among white cases (n = 441 to 453) and controls (n = 487 to 526). We found no evidence of an association between XRCC1 genotypes and glioma. We observed a weak positive association for the MGMT Leu84Phe polymorphism (Leu or Phe/Phe versus Leu/Leu: adjusted OR = 1.26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71). Copyright (c) 2007 S. Karger AG, Basel.

URL

http://dx.doi.org/10.1159/000108919

Reference Type

Journal Article

Year Published

2007

Journal Title

Neuroepidemiology

Author(s)

Felini, Martha J.
Olshan, Andrew F.
Schroeder, Jane C.
North, Kari E.
Carozza, Susan E.
Kelsey, Karl T.
Liu, Mei
Rice, Terri
Wiencke, John K.
Wrensch, Margaret R.

ORCiD

Olshan - 0000-0001-9115-5128