The Effect of Maternal Body Mass Index on Neonatal Outcome in Women Receiving a Single Course of Antenatal Corticosteroids

Citation

Hashima, Jason N.; Lai, Yinglei; Wapner, Ronald J.; Sorokin, Yoram; Dudley, Donald J.; Peaceman, Alan M.; Spong, Catherine Y.; Iams, Jay D.; Leveno, Kenneth J.; & Harper, Margaret A., et al. (2010). The Effect of Maternal Body Mass Index on Neonatal Outcome in Women Receiving a Single Course of Antenatal Corticosteroids. American Journal of Obstetrics & Gynecology, 202(3), 263.e1-5. PMCID: PMC2834852

Abstract

OBJECTIVE: The aim of this study was to determine the effect of maternal body mass index on the incidence of neonatal prematurity morbidities in those who receive corticosteroids.
STUDY DESIGN: This was a secondary analysis of a trial of corticosteroids in women at risk for preterm birth. Women receiving a single course of corticosteroids were classified by their prepregnancy body mass index (<25 and >/=25) and compared on a composite outcome comprised of several neonatal morbidities and on each individual outcome.
RESULTS: Of 183 eligible women, 96 (52.5%) had a body mass index of <25 and 87 (47.5%) had a body mass index of >/=25. The composite outcome occurred more frequently in the body mass index of >/=25 group (28.7%), compared with those with a body mass index of <25 (18.8%), although this was not statistically significant (odds ratio, 1.75; 95% confidence interval, 0.83-3.72). Body mass index was not associated with outcomes after adjusting for confounding.
CONCLUSION: Maternal body mass index did not affect neonatal prematurity morbidities in those receiving corticosteroids.

URL

http://dx.doi.org/10.1016/j.ajog.2009.10.859

Reference Type

Journal Article

Year Published

2010

Journal Title

American Journal of Obstetrics & Gynecology

Author(s)

Hashima, Jason N.
Lai, Yinglei
Wapner, Ronald J.
Sorokin, Yoram
Dudley, Donald J.
Peaceman, Alan M.
Spong, Catherine Y.
Iams, Jay D.
Leveno, Kenneth J.
Harper, Margaret A.
Caritis, Steve N.
Varner, Michael W.
Miodovnik, Menachem
Mercer, Brian M.
Thorp, John M., Jr.
O'Sullivan, Mary Jo
Ramin, Susan M.
Carpenter, Marshall W.
Rouse, Dwight J.
Sibai, Baha M., for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network

PMCID

PMC2834852

ORCiD

Thorp - 0000-0002-9307-6690