Body Mass Index and Risk of Head and Neck Cancer in a Pooled Analysis of Case-Control Studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

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Gaudet, Mia M.; Olshan, Andrew F.; Chuang, Shu-Chun; Berthiller, Julien; Zhang, Zuo-Feng; Lissowska, Jolanta; Zaridze, David; Winn, Deborah M.; Wei, Qingyi; & Talamini, Renato, et al. (2010). Body Mass Index and Risk of Head and Neck Cancer in a Pooled Analysis of Case-Control Studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. International Journal of Epidemiology, 39(4), 1091-1102. PMCID: PMC2929351

Abstract

BACKGROUND: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases.
METHODS: We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption.
RESULTS: Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) 25.0-30.0 kg/m(2) (0.52, 0.44-0.60) and BMI >/=30 kg/m(2) (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m(2). These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI 25 kg/m(2) was present only in smokers and drinkers.
CONCLUSIONS: In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.

URL

http://dx.doi.org/10.1093/ije/dyp380

Reference Type

Journal Article

Year Published

2010

Journal Title

International Journal of Epidemiology

Author(s)

Gaudet, Mia M.
Olshan, Andrew F.
Chuang, Shu-Chun
Berthiller, Julien
Zhang, Zuo-Feng
Lissowska, Jolanta
Zaridze, David
Winn, Deborah M.
Wei, Qingyi
Talamini, Renato
Szeszenia-Dabrowska, Neonila
Sturgis, Erich M.
Schwartz, Stephen M.
Rudnai, Peter
Eluf-Neto, Jose
Muscat, Joshua E.
Morgenstern, Hal
Menezes, Ana M.
Matos, Elena L.
Bucur, Alexandru
Levi, Fabio
Lazarus, Philip
La Vecchia, Carlo
Koifman, Sergio
Kelsey, Karl T.
Herrero, Rolando
Hayes, Richard B.
Franceschi, Silvia
Wunsch-Filho, Victor
Fernandez, Leticia
Fabianova, Eleonora
Daudt, Alexander W.
Dal Maso, Luigino
Curado, Maria Paula
Chen, Chu
Castellsague, Xavier
Benhamou, Simone
Boffetta, Paolo
Brennan, Paul
Hashibe, Mia

PMCID

PMC2929351

ORCiD

Olshan - 0000-0001-9115-5128