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Genome-Wide Association with C-Reactive Protein Levels in CLHNS: Evidence for the CRP and HNF1A Loci and Their Interaction with Exposure to a Pathogenic Environment

Citation

Wu, Ying; McDade, Thomas W.; Kuzawa, Christopher W.; Borja, Judith B.; Li, Yun; Adair, Linda S.; Mohlke, Karen L.; & Lange, Leslie A. (2012). Genome-Wide Association with C-Reactive Protein Levels in CLHNS: Evidence for the CRP and HNF1A Loci and Their Interaction with Exposure to a Pathogenic Environment. Inflammation, 35(2), 574-583. PMCID: PMC3193904

Abstract

Recent genome-wide association studies have related several genetic loci, including C-reactive protein (CRP), hepatocyte nuclear factor 1 homeobox (HNF1A), and genetic variations in the leptin receptor (LEPR), to circulating CRP levels in populations of European ancestry. The genetic effects in other populations and across varying levels of exposure to a pathogenic environment, an important environmental factor associated with CRP, remain to be determined. We tested 2,073,674 single-nucleotide polymorphisms (SNPs) for association with plasma CRP (limited to ≤10 mg/L) in 1,709 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey. The strongest evidence of association was observed with variants at CRP (rs876537, P = 1.4 × 10(-9)) and HNF1A (rs7305618, P = 1.0 × 10(-8)). Among other previously reported CRP-associated loci, the apolipoprotein E

URL

http://dx.doi.org/10.1007/s10753-011-9348-y

Reference Type

Journal Article

Year Published

2012

Journal Title

Inflammation

Author(s)

Wu, Ying
McDade, Thomas W.
Kuzawa, Christopher W.
Borja, Judith B.
Li, Yun
Adair, Linda S.
Mohlke, Karen L.
Lange, Leslie A.

PMCID

PMC3193904