An Examination of Male and Female Odds Ratios by BMI, Cigarette Smoking, and Alcohol Consumption for Cancers of the Oral Cavity, Pharynx, and Larynx in Pooled Data from 15 Case-Control Studies

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Lubin, Jay H.; Muscat, Joshua E.; Gaudet, Mia M.; Olshan, Andrew F.; Curado, Maria Paula; Dal Maso, Luigino; Wunsch-Filho, Victor; Sturgis, Erich M.; Szeszenia-Dabrowska, Neonila; & Castellsague, Xavier, et al. (2011). An Examination of Male and Female Odds Ratios by BMI, Cigarette Smoking, and Alcohol Consumption for Cancers of the Oral Cavity, Pharynx, and Larynx in Pooled Data from 15 Case-Control Studies. Cancer Causes & Control, 22(9), 1217-1231. PMCID: PMC3304584

Abstract

BACKGROUND: Greater tobacco smoking and alcohol consumption and lower body mass index (BMI) increase odds ratios (OR) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ORs for these factors.
METHODS: We analyzed 2,441 oral cavity (925 women and 1,516 men), 2,297 oropharynx (564 women and 1,733 men), 508 hypopharynx (96 women and 412 men), and 1,740 larynx (237 women and 1,503 men) cases from the INHANCE consortium of 15 head and neck cancer case-control studies. Controls numbered from 7,604 to 13,829 subjects, depending on analysis. Analyses fitted linear-exponential excess ORs models.
RESULTS: ORs were increased in underweight (<18.5 BMI) relative to normal weight (18.5-24.9) and reduced in overweight and obese categories (>/=25 BMI) for all sites and were homogeneous by sex. ORs by smoking and drinking in women compared with men were significantly greater for oropharyngeal cancer (p < 0.01 for both factors), suggestive for hypopharyngeal cancer (p = 0.05 and p = 0.06, respectively), but homogeneous for oral cavity (p = 0.56 and p = 0.64) and laryngeal (p = 0.18 and p = 0.72) cancers.
CONCLUSIONS: The extent that OR modifications of smoking and drinking by sex for oropharyngeal and, possibly, hypopharyngeal cancers represent true associations, or derive from unmeasured confounders or unobserved sex-related disease subtypes (e.g., human papillomavirus-positive oropharyngeal cancer) remains to be clarified.

URL

http://dx.doi.org/10.1007/s10552-011-9792-x

Reference Type

Journal Article

Year Published

2011

Journal Title

Cancer Causes & Control

Author(s)

Lubin, Jay H.
Muscat, Joshua E.
Gaudet, Mia M.
Olshan, Andrew F.
Curado, Maria Paula
Dal Maso, Luigino
Wunsch-Filho, Victor
Sturgis, Erich M.
Szeszenia-Dabrowska, Neonila
Castellsague, Xavier
Zhang, Zuo-Feng
Smith, Elaine
Fernandez, Leticia
Matos, Elena L.
Franceschi, Silvia
Fabianova, Eleonora
Rudnai, Peter
Purdue, Mark P.
Mates, Dana
Wei, Qingyi
Herrero, Rolando
Kelsey, Karl T.
Morgenstern, Hal
Shangina, Oxana
Koifman, Sergio
Lissowska, Jolanta
Levi, Fabio
Daudt, Alexander W.
Eluf-Neto, Jose
Chen, Chu
Lazarus, Philip
Winn, Deborah M.
Schwartz, Stephen M.
Boffetta, Paolo
Brennan, Paul
Menezes, Ana M.
La Vecchia, Carlo
McClean, Michael D.
Talamini, Renato
Rajkumar, Thangarajan
Hayes, Richard B.
Hashibe, Mia

PMCID

PMC3304584

ORCiD

Olshan - 0000-0001-9115-5128