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Natural Cholera Infection-Derived Immunity in an Endemic Setting

Citation

Ali, Mohammad; Emch, Michael E.; Park, Jin Kyung; Yunus, Mohammad; & Clemens, John D. (2011). Natural Cholera Infection-Derived Immunity in an Endemic Setting. Journal of Infectious Diseases, 204(6), 912-918. PMCID: PMC3156915

Abstract

Background: Live oral cholera vaccines may protect against cholera in a manner similar to natural cholera infections. However, information on which to base these vaccines is limited.
Methods: The study was conducted in a cholera-endemic population in Bangladesh. Patients with cholera (index patients) detected between 1991 and 2000 were age-matched to 4 cholera-free controls and then followed up during the subsequent 3 years.
Results: El Tor cholera was associated with a 65% (95% confidence interval [CI], 37%-81%; P < .001) lower risk of a subsequent El Tor episode. Reduction of the risk of subsequent El Tor cholera was similar for children <5 years and for older persons and was sustained during all 3 years of follow-up. Having El Tor Inaba cholera was associated with lower risks of both El Tor Inaba and El Tor Ogawa cholera, but having El Tor Ogawa cholera was associated only with a reduced risk of El Tor Ogawa cholera. O139 cholera was associated with a 63% (95% CI, -61% to 92%; P = .18) lower risk of subsequent O139 cholera, but there was no evidence of cross-protection between the O1 and O139 serogroups.
Conclusions: Live oral cholera vaccines designed to protect against the O1 and O139 serogroups should contain at least the Inaba serotype and strains of both serogroups.

URL

http://dx.doi.org/10.1093/infdis/jir416

Reference Type

Journal Article

Year Published

2011

Journal Title

Journal of Infectious Diseases

Author(s)

Ali, Mohammad
Emch, Michael E.
Park, Jin Kyung
Yunus, Mohammad
Clemens, John D.

PMCID

PMC3156915