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Population-Specific Coding Variant Underlies Genome-Wide Association with Adiponectin Level

Citation

Croteau-Chonka, Damien C.; Wu, Ying; Li, Yun; Fogarty, Marie P.; Lange, Leslie A.; Kuzawa, Christopher W.; McDade, Thomas W.; Borja, Judith B.; Luo, Jingchun; & AbdelBaky, Omar, et al. (2012). Population-Specific Coding Variant Underlies Genome-Wide Association with Adiponectin Level. Human Molecular Genetics, 21(2), 463-471. PMCID: PMC3276282

Abstract

Adiponectin is a protein hormone that can affect major metabolic processes including glucose regulation and fat metabolism. Our previous genome-wide association (GWA) study of circulating plasma adiponectin levels in Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) detected a 100 kb two-SNP haplotype at KNG1–ADIPOQ associated with reduced adiponectin (frequency 5 0.050, P 5 1.8 3 10225). Subsequent genotyping of CLHNS young adult offspring detected an uncommon variant [minor allele frequency (MAF) 5 0.025] located

URL

http://dx.doi.org/10.1093/hmg/ddr480

Reference Type

Journal Article

Year Published

2012

Journal Title

Human Molecular Genetics

Author(s)

Croteau-Chonka, Damien C.
Wu, Ying
Li, Yun
Fogarty, Marie P.
Lange, Leslie A.
Kuzawa, Christopher W.
McDade, Thomas W.
Borja, Judith B.
Luo, Jingchun
AbdelBaky, Omar
Combs, Terry P.
Adair, Linda S.
Lange, Ethan M.
Mohlke, Karen L.

PMCID

PMC3276282