Citation
Bradshaw, Patrick T.; Siega-Riz, Anna Maria; Campbell, Marci Kramish; Weissler, Mark Christian; Funkhouser, William K.; & Olshan, Andrew F. (2012). Associations between Dietary Patterns and Head and Neck Cancer: The Carolina Head and Neck Cancer Epidemiology Study. American Journal of Epidemiology, 175(12), 1225-1233. PMCID: PMC3372316Abstract
Few studies have examined the associations between dietary patterns and head and neck squamous cell carcinoma (SCC) or whether they differ by race. This was evaluated using data from a population-based case-control study (2002-2006) including 1,176 cases of head and neck SCC and 1,317 age-, race-, and gender-matched controls from central and eastern North Carolina whose diets had been assessed by food frequency questionnaire. Factor analysis identified 2 patterns of intake: 1) high consumption of fruits, vegetables, and lean protein and 2) high consumption of fried foods, high-fat and processed meats, and sweets. Associations were estimated using logistic regression, adjusting for matching factors and confounders. Heterogeneity by tumor site (oral/pharyngeal vs. laryngeal) and effect-measure modification were also evaluated. Reduced odds of head and neck SCC were found for the fruit, vegetable, and lean protein pattern (for highest quartile vs. lowest, odds ratio = 0.53, 95% confidence interval: 0.39, 0.71). The fried foods, high-fat and processed meats, and sweets pattern was positively associated only with laryngeal cancer (odds ratio = 2.12, 95% confidence interval: 1.21, 3.72). These findings underline the importance of a dietary pattern rich in fruits and vegetables and low in high-fat and processed meats and sweets for prevention of head and neck cancer.URL
http://dx.doi.org/10.1093/aje/kwr468Reference Type
Journal ArticleYear Published
2012Journal Title
American Journal of EpidemiologyAuthor(s)
Bradshaw, Patrick T.Siega-Riz, Anna Maria
Campbell, Marci Kramish
Weissler, Mark Christian
Funkhouser, William K.
Olshan, Andrew F.
PMCID
PMC3372316ORCiD
Olshan - 0000-0001-9115-5128Siega-Riz - 0000-0002-1303-4248