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Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Citation

Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas J.; Perry, John R. B.; Yuan, Xin; Scott, Robert A.; Henneman, Peter; Heid, Iris M.; Kizer, Jorge R.; & Lyytikäinen, Leo-Pekka, et al. (2012). Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals. PLOS Genetics, 8(3), e1002607. PMCID: PMC3315470

Abstract

Serum adiponectin levels are highly heritable and are inversely correlated with the risk of type 2 diabetes (T2D), coronary artery disease, stroke, and several metabolic traits. To identify common genetic variants associated with adiponectin levels and risk of T2D and metabolic traits, we conducted a meta-analysis of genome-wide association studies of 45,891 multi-ethnic individuals. In addition to confirming that variants at the

URL

http://dx.doi.org/10.1371%2Fjournal.pgen.1002607

Reference Type

Journal Article

Year Published

2012

Journal Title

PLOS Genetics

Author(s)

Dastani, Zari
Hivert, Marie-France
Timpson, Nicholas J.
Perry, John R. B.
Yuan, Xin
Scott, Robert A.
Henneman, Peter
Heid, Iris M.
Kizer, Jorge R.
Lyytikäinen, Leo-Pekka
Fuchsberger, Christian
Tanaka, Toshiko
Morris, Andrew P.
Small, Kerrin S.
Isaacs, Aaron J.
Beekman, Marian
Coassin, Stefan
Lohman, Kurt K.
Qi, Lu
Kanoni, Stavroula
Pankow, James S.
Uh, Hae-Won
Wu, Ying
Bidulescu, Aurelian
Rasmussen-Torvik, Laura J.
Greenwood, Celia M. T.
Ladouceur, Martin
Grimsby, Jonna
Manning, Alisa K.
Liu, Ching-Ti
Kooner, Jaspal Singh S.
Mooser, Vincent E.
Vollenweider, Peter
Kapur, Karen A.
Chambers, John C.
Wareham, Nicholas J.
Langenberg, Claudia
Frants, Rune
Willems van Dijk, Ko
Oostra, Ben A.
Willems, Sara M.
Lamina, Claudia
Winkler, Thomas W.
Psaty, Bruce M.
Tracy, Russell P.
Brody, Jennifer A.
Chen, Ida
Viikari, Jorma S.
Kähönen, Mika
Pramstaller, Peter P.
Evans, David M.
St. Pourcain, Beate
Sattar, Naveed
Wood, Andrew R.
Bandinelli, Stefania
Carlson, Olga D.
Egan, Josephine M.
Böhringer, Stefan
van Heemst, Diana
Kedenko, Lyudmyla
Kristiansson, Kati
Nuotio, Marja-Liisa
Loo, Britt-Marie
Harris, Tamara B.
Garcia, Melissa E.
Kanaya, Alka
Haun, Margot
Klopp, Norman
Wichmann, H. Erich
Deloukas, Panos
Katsareli, Efi
Couper, David J.
Duncan, Bruce B.
Kloppenburg, Margreet
Adair, Linda S.
Borja, Judith B.
DIAGRAM Consortium,
MAGIC Consortium,
GLGC Investigators,
MuTHER Consortium,
Wilson, James G.
Musani, Solomon K.
Guo, Xiuqing
Johnson, Toby
Semple, Robert
Teslovich, Tanya M.
Allison, Matthew A.
Redline, Susan S.
Buxbaum, Sarah G.
Mohlke, Karen L.
Meulenbelt, Ingrid
Ballantyne, Christie M.
Dedoussis, George
Hu, Frank B.
Liu, Yongmei
Paulweber, Bernhard
Spector, Timothy D.
Slagboom, P. Eline
Ferrucci, Luigi
Jula, Antti M.
Perola, Markus
Raitakari, Olli T.
Florez, Jose C.
Salomaa, Veikko
Eriksson, Johan G.
Frayling, Timothy M.
Hicks, Andrew A.
Lehtimäki, Terho
Smith, George Davey
Siscovick, David S.
Kronenberg, Florian
van Duijn, Cornelia M.
Loos, Ruth J. F.
Waterworth, Dawn M.
Meigs, James B.
Dupuis, Josee
Richards, J. Brent

PMCID

PMC3315470