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Meta-Analysis of Genome-Wide Association Studies Identifies Eight New Loci for Type 2 Diabetes in East Asians

Citation

Cho, Yoon Shin; Chen, Chien-Hsiun; Hu, Cheng; Long, Jirong; Hee Ong, Rick Twee; Sim, Xueling; Takeuchi, Fumihiko; Wu, Ying; Go, Min Jin; & Yamauchi, Toshimasa, et al. (2012). Meta-Analysis of Genome-Wide Association Studies Identifies Eight New Loci for Type 2 Diabetes in East Asians. Nature Genetics, 44(1), 67-72. PMCID: PMC3582398

Abstract

We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in East Asian populations. The first stage meta-analysis of eight T2D genome-wide association studies (6,952 cases and 11,865 controls) was followed by a second stage in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which were mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, involved in pancreatic beta cell development and insulin gene expression1,2, is known for its association with fasting glucose levels3,4. The evidence of T2D association for PEPD5 and HNF4A6,7 has been detected in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings derived from East Asians provide new perspectives on the etiology of T2D.

URL

http://dx.doi.org/10.1038/ng.1019

Reference Type

Journal Article

Year Published

2012

Journal Title

Nature Genetics

Author(s)

Cho, Yoon Shin
Chen, Chien-Hsiun
Hu, Cheng
Long, Jirong
Hee Ong, Rick Twee
Sim, Xueling
Takeuchi, Fumihiko
Wu, Ying
Go, Min Jin
Yamauchi, Toshimasa
Chang, Yi-Cheng
Kwak, Soo Heon
Ma, Ronald C. W.
Yamamoto, Ken
Adair, Linda S.
Aung, Tin
Cai, Qiuyin
Chang, Li-Ching
Chen, Yuan-Tsong
Gao, Yu-Tang
Hu, Frank B.
Kim, Hyung-Lae
Kim, Sangsoo
Kim, Young Jin
Lee, Jeannette
Lee, Nanette R.
Li, Yun
Liu, Jianjun
Lu, Wei
Nakamura, Jiro
Nakashima, Eitaro
Ng, Daniel Peng-Keat
Tay, Wan Ting
Tsai, Fuu-Jen
Wong, Tien Yin
Yokota, Mitsuhiro
Zheng, Wei
Zhang, Rong
Wang, Congrong
So, Wing Yee
Ohnaka, Keizo
Ikegami, Hiroshi
Hara, Kazuo
Cho, Young Min
Cho, Nam H.
Chang, Tien-Jyun
Bao, Yuqian
Hedman, Asa K.
Morris, Andrew P.
McCarthy, Mark I.
Takayanagi, Ryoichi
Park, Kyong Soo
Jia, Weiping
Chuang, Lee-Ming
Chan, Juliana C. N.
Maeda, Shiro
Kadowaki, Takashi
Lee, Jong-Young
Wu, Jer-Yuarn
Teo, Yik Ying
Tai, E. Shyong
Shu, Xiao -u
Mohlke, Karen L.
Kato, Norihiro
Han, Bok-Ghee
Seielstad, Mark

PMCID

PMC3582398