A Meta-Analysis Identifies New Loci Associated with Body Mass Index in Individuals of African Ancestry

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Citation

Monda, Keri L.; Chen, Gary K.; Taylor, Kira C.; Palmer, Cameron D.; Edwards, Todd L.; Lange, Leslie A.; Ng, Maggie C. Y.; Adeyemo, Adebowale A.; Allison, Matthew A.; & Bielak, Lawrence F., et al. (2013). A Meta-Analysis Identifies New Loci Associated with Body Mass Index in Individuals of African Ancestry. Nature Genetics, 45(6), 690-696. PMCID: PMC3694490

Abstract

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10-8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.

URL

http://dx.doi.org/10.1038/ng.2608

Reference Type

Journal Article

Year Published

2013

Journal Title

Nature Genetics

Author(s)

Monda, Keri L.
Chen, Gary K.
Taylor, Kira C.
Palmer, Cameron D.
Edwards, Todd L.
Lange, Leslie A.
Ng, Maggie C. Y.
Adeyemo, Adebowale A.
Allison, Matthew A.
Bielak, Lawrence F.
Chen, Guanjie
Graff, Mariaelisa
Irvin, Marguerite Ryan
Rhie, Suhn K.
Li, Guo
Liu, Yongmei
Liu, Youfang
Lu, Yingchang
Nalls, Michael A.
Sun, Yan V.
Wojczynski, Mary K.
Yanek, Lisa R.
Aldrich, Melinda C.
Ademola, Adeyinka
Amos, Christopher I.
Bandera, Elisa V.
Bock, Cathryn H.
Britton, Angela
Broeckel, Ulrich
Cai, Qiuyin
Caporaso, Neil E.
Carlson, Christopher S.
Carpten, John
Casey, Graham
Chen, Wei-Min
Chen, Fang
Chen, Yii-Der Ida
Chiang, Charleston W. K.
Coetzee, Gerhard A.
Demerath, Ellen W.
Deming-Halverson, Sandra L.
Driver, Ryan W.
Dubbert, Patricia
Feitosa, Mary F.
Feng, Ye
Freedman, Barry I.
Gillanders, Elizabeth M.
Gottesman, Omri
Guo, Xiuqing
Haritunians, Talin
Harris, Tamara B.
Harris, Curtis C.
Hennis, Anselm J.
Hernandez, Dena
McNeill, Lorna H.
Howard, Timothy D.
Howard, Barbara V.
Howard, Virginia J.
Johnson, Karen C.
Kang, Sun J.
Keating, Brendan J.
Kolb, Suzanne
Kuller, Lewis H.
Kutlar, Abdullah
Langefeld, Carl D.
Lettre, Guillaume
Lohman, Kurt K.
Lotay, Vaneet
Lyon, Helen N.
Manson, JoAnn E.
Maixner, William
Meng, Yan A.
Monroe, Kristine R.
Morhason-Bello, Imran
Murphy, Adam B.
Mychaleckyj, Josyf C.
Nadukuru, Rajiv
Nathanson, Katherine L.
Nayak, Uma
N'Diaye, Amidou
Nemesure, Barbara
Wu, Suh-Yuh
Leske, M. Cristina
Neslund-Dudas, Christine
Neuhouser, Marian L.
Nyante, Sarah J.
Ochs-Balcom, Heather M.
Ogunniyi, Adesola
Ogundiran, Temidayo O.
Ojengbede, Oladosu
Olopade, Olufunmilayo I.
Palmer, Julie R.
Ruiz-Narvaez, Edward A.
Palmer, Nicholette D.
Press, Michael F.
Rampersaud, Evandine
Rasmussen-Torvik, Laura J.
Rodriguez-Gil, Jorge L.
Salako, Babatunde
Schadt, Eric E.
Schwartz, Ann G.
Shriner, Daniel A.
Siscovick, David S.
Smith, Shad B.
Wassertheil-Smoller, Sylvia
Speliotes, Elizabeth K.
Spitz, Margaret R.
Sucheston, Lara
Taylor, Herman A., Jr.
Tayo, Bamidele O.
Tucker, Margaret A.
Van Den Berg, David J.
Edwards, Digna R. Velez
Wang, Zhaoming
Wiencke, John K.
Winkler, Thomas W.
Witte, John S.
Wrensch, Margaret R.
Wu, Xifeng
Yang, James J.
Levin, Albert M.
Young, Taylor R.
Zakai, Neil A.
Cushman, Mary
Zanetti, Krista A.
Zhao, Jing Hua
Zhao, Wei
Zheng, Yonglan
Zhou, Jie
Ziegler, Regina G.
Zmuda, Joseph M.
Fernandes, Jyotika K.
Gilkeson, Gary S.
Kamen, Diane L.
Hunt, Kelly J.
Spruill, Ida J.
Ambrosone, Christine B.
Ambs, Stefan
Arnett, Donna K.
Atwood, Larry D.
Becker, Diane M.
Berndt, Sonja I.
Bernstein, Leslie
Blot, William J.
Borecki, Ingrid B.
Bottinger, Erwin P.
Bowden, Donald W.
Burke, Gregory
Chanock, Stephen J.
Cooper, Richard S.
Ding, Jingzhong
Duggan, David
Evans, Michele K.
Fox, Caroline S.
Garvey, W. Timothy
Bradfield, Jonathan P.
Hakonarson, Hakon
Grant, Struan F. A.
Hsing, Ann W.
Chu, Lisa
Hu, Jennifer J.
Huo, Dezheng
Ingles, Sue Ann
John, Esther M.
Jordan, Joanne M.
Kabagambe, Edmond K.
Kardia, Sharon L. R.
Kittles, Rick A.
Goodman, Phyllis J.
Klein, Eric A.
Kolonel, Laurence N.
Le Marchand, Loic
Liu, Simin
McKnight, Barbara
Millikan, Robert C.
Mosley, Thomas H., Jr.
Padhukasahasram, Badri
Williams, L. Keoki
Patel, Sanjay R.
Peters, Ulrike
Pettaway, Curtis A.
Peyser, Patricia A.
Psaty, Bruce M.
Redline, Susan S.
Rotimi, Charles N.
Rybicki, Benjamin A.
Sale, Michele M.
Schreiner, Pamela J.
Signorello, Lisa B.
Singleton, Andrew B.
Stanford, Janet L.
Strom, Sara S.
Thun, Michael J.
Vitolins, Mara Z.
Zheng, Wei
Moore, Jason H.
Williams, Scott M.
Ketkar, Shamika
Zhu, Xiaofeng
Zonderman, Alan B.
Kooperberg, Charles L.
Papanicolaou, George J.
Henderson, Brian E.
Reiner, Alexander P.
Hirschhorn, Joel N.
Loos, Ruth J. F.
North, Kari E.
Haiman, Christopher A.

PMCID

PMC3694490

ORCiD

Graff - 0000-0001-6380-1735