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Meeting Physical Activity Guidelines and the Risk of Incident Knee Osteoarthritis: A Population-Based Prospective Cohort Study

Citation

Barbour, Kamil E.; Hootman, Jennifer M.; Helmick, Charles G.; Murphy, Louise B.; Theis, Kristina A.; Schwartz, Todd A.; Kalsbeek, William D.; Renner, Jordan B.; & Jordan, Joanne M. (2014). Meeting Physical Activity Guidelines and the Risk of Incident Knee Osteoarthritis: A Population-Based Prospective Cohort Study. Arthritis Care & Research, 66(1), 139-146. PMCID: PMC4309362

Abstract

Objective: Knee osteoarthritis (OA) remains a leading cause of disability and joint pain. Though other risk factors of knee OA have been identified, how physical activity affects incident knee OA remains unclear.
Methods: Using data from the Johnston County Osteoarthritis Project study's first (1999-2004) and second follow-up (2005-2010), we tested the association between meeting physical activity guidelines and incident knee outcomes among 1522 adults aged ≥45 years. The median (range) follow-up time was 6.5 (4.0-10.2) years. Physical activity at baseline (moderate-equivalent min/week) was calculated using the Minnesota Leisure Time Physical Activity questionnaire. Incident knee radiographic OA (ROA) was defined as the development of a Kellgren-Lawrence grade of ≥2 in a knee at follow-up. Incident knee symptomatic ROA (sROA) was defined as the development of ROA and symptoms in at least one knee at follow-up. Weibull regression modeling was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for interval censored data.
Results: In multivariable models, meeting the 2008 HHS physical activity guidelines (≥150 min/week) was not significantly associated with ROA (HR: 1.20; 95% CI=0.94, 1.56) or sROA (HR: 1.24; 95% CI=0.87, 1.76). Adults in the highest (≥300 min/week) level of physical activity had a higher risk of knee ROA and sROA compared with inactive (0-<10 min/week) participants; however these associations were not statistically significant (HR: 1.62; 95% CI=0.97, 2.68 and HR: 1.42; 95% CI=0.76, 2.65, respectively).
Conclusion: Meeting HHS physical activity guidelines was not associated with incident knee ROA or sROA in a cohort of middle-aged and older adults.

URL

http://dx.doi.org/10.1002/acr.22120

Reference Type

Journal Article

Year Published

2014

Journal Title

Arthritis Care & Research

Author(s)

Barbour, Kamil E.
Hootman, Jennifer M.
Helmick, Charles G.
Murphy, Louise B.
Theis, Kristina A.
Schwartz, Todd A.
Kalsbeek, William D.
Renner, Jordan B.
Jordan, Joanne M.

PMCID

PMC4309362