CitationBarbour, Kamil E.; Hootman, Jennifer M.; Helmick, Charles G.; Murphy, Louise B.; Theis, Kristina A.; Schwartz, Todd A.; Kalsbeek, William D.; Renner, Jordan B.; & Jordan, Joanne M. (2014). Meeting Physical Activity Guidelines and the Risk of Incident Knee Osteoarthritis: A Population-Based Prospective Cohort Study. Arthritis Care & Research, 66(1), 139-146. PMCID: PMC4309362
AbstractObjective: Knee osteoarthritis (OA) remains a leading cause of disability and joint pain. Though other risk factors of knee OA have been identified, how physical activity affects incident knee OA remains unclear.
Methods: Using data from the Johnston County Osteoarthritis Project study's first (1999-2004) and second follow-up (2005-2010), we tested the association between meeting physical activity guidelines and incident knee outcomes among 1522 adults aged ≥45 years. The median (range) follow-up time was 6.5 (4.0-10.2) years. Physical activity at baseline (moderate-equivalent min/week) was calculated using the Minnesota Leisure Time Physical Activity questionnaire. Incident knee radiographic OA (ROA) was defined as the development of a Kellgren-Lawrence grade of ≥2 in a knee at follow-up. Incident knee symptomatic ROA (sROA) was defined as the development of ROA and symptoms in at least one knee at follow-up. Weibull regression modeling was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for interval censored data.
Results: In multivariable models, meeting the 2008 HHS physical activity guidelines (≥150 min/week) was not significantly associated with ROA (HR: 1.20; 95% CI=0.94, 1.56) or sROA (HR: 1.24; 95% CI=0.87, 1.76). Adults in the highest (≥300 min/week) level of physical activity had a higher risk of knee ROA and sROA compared with inactive (0-<10 min/week) participants; however these associations were not statistically significant (HR: 1.62; 95% CI=0.97, 2.68 and HR: 1.42; 95% CI=0.76, 2.65, respectively).
Conclusion: Meeting HHS physical activity guidelines was not associated with incident knee ROA or sROA in a cohort of middle-aged and older adults.
Reference TypeJournal Article
Journal TitleArthritis Care & Research
Author(s)Barbour, Kamil E.
Hootman, Jennifer M.
Helmick, Charles G.
Murphy, Louise B.
Theis, Kristina A.
Schwartz, Todd A.
Kalsbeek, William D.
Renner, Jordan B.
Jordan, Joanne M.