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Folate Intake and the Risk of Oral Cavity and Pharyngeal Cancer: A Pooled Analysis within the International Head and Neck Cancer Epidemiology Consortium

Citation

Galeone, Carlotta; Edefonti, Valeria; Parpinel, Maria; Leoncini, Emanuele; Matsuo, Keitaro; Talamini, Renato; Olshan, Andrew F.; Zevallos, Jose P.; Winn, Deborah M.; & Jayaprakash, Vijayvel, et al. (2015). Folate Intake and the Risk of Oral Cavity and Pharyngeal Cancer: A Pooled Analysis within the International Head and Neck Cancer Epidemiology Consortium. International Journal of Cancer, 136(4), 904-914. PMCID: PMC4262536

Abstract

There are suggestions of an inverse association between folate intake and serum folate levels and the risk of oral cavity and pharyngeal cancers (OPC), but most studies are limited in sample size, with only few reporting information on the source of dietary folate. This study aims to investigate the association between folate intake and the risk of OPC within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. We analyzed pooled individual-level data from 10 case-control studies participating in the INHANCE consortium, including 5,127 cases and 13,249 controls. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated for the associations between total folate intake (natural, fortification and supplementation) and natural folate only, and OPC risk. We found an inverse association between total folate intake and overall OPC risk (the adjusted OR for the highest versus the lowest quintile was 0.65, 95% CI: 0.43-0.99), with a stronger association for oral cavity (OR=0.57, 95% CI: 0.43-0.75). A similar inverse association, though somewhat weaker, was observed for folate intake from natural sources only (OR=0.64, 95% CI: 0.45-0.91). The highest OPC risk was observed in heavy alcohol drinkers with low folate intake as compared to never/light drinkers with high folate (OR=4.05, 95% CI: 3.43-4.79); the attributable proportion due to interaction was 11.1%(95% CI: 1.4-20.8%). The present project of a large pool of case-control studies supports a protective effect total folate intake on OPC risk.

URL

http://dx.doi.org/10.1002/ijc.29044

Reference Type

Journal Article

Year Published

2015

Journal Title

International Journal of Cancer

Author(s)

Galeone, Carlotta
Edefonti, Valeria
Parpinel, Maria
Leoncini, Emanuele
Matsuo, Keitaro
Talamini, Renato
Olshan, Andrew F.
Zevallos, Jose P.
Winn, Deborah M.
Jayaprakash, Vijayvel
Moysich, Kirsten
Zhang, Zuo-Feng
Morgenstern, Hal
Levi, Fabio
Bosetti, Cristina
Kelsey, Karl T.
McClean, Michael D.
Schantz, Stimson
Yu, Guo-Pei
Boffetta, Paolo
Lee, Yuan-Chin Amy
Hashibe, Mia
La Vecchia, Carlo
Boccia, Stefania

PMCID

PMC4262536