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Motoric Cognitive Risk Syndrome: Multicountry Prevalence and Dementia Risk


Verghese, Joe; Annweiler, Cedric; Ayers, Emmeline; Barzilai, Nir; Beauchet, Olivier; Bennett, David A.; Bridenbaugh, Stephanie A.; Buchman, Aron S.; Callisaya, Michele L.; & Camicioli, Richard, et al. (2014). Motoric Cognitive Risk Syndrome: Multicountry Prevalence and Dementia Risk. Neurology, 83(8), 718-726. PMCID: PMC4150127


OBJECTIVES: Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk.
METHODS: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline >/=4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini-Mental State Examination scores >/=25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.
RESULTS: At baseline, 2,808 of the 26,802 participants met MCR criteria. Pooled MCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes.
CONCLUSION: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.


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Journal Article

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Verghese, Joe
Annweiler, Cedric
Ayers, Emmeline
Barzilai, Nir
Beauchet, Olivier
Bennett, David A.
Bridenbaugh, Stephanie A.
Buchman, Aron S.
Callisaya, Michele L.
Camicioli, Richard
Capistrant, Benjamin D.
Chatterji, Somnath
De Cock, Anne-Marie
Ferrucci, Luigi
Giladi, Nir
Guralnik, Jack M.
Hausdorff, Jeffrey M.
Holtzer, Roee
Kim, Ki Woong
Kowal, Paul
Kressig, Reto W.
Lim, Jae-Young
Lord, Susan
Meguro, Kenichi
Montero-Odasso, Manuel
Muir-Hunter, Susan W.
Noone, Mohan L.
Rochester, Lynn
Srikanth, Velandai
Wang, Cuiling