CitationZeki Al Hazzouri, Adina; Haan, Mary N.; Kalbfleisch, John D.; Galea, Sandro; Lisabeth, Lynda D.; & Aiello, Allison E. (2011). Life-Course Socioeconomic Position and Incidence of Dementia and Cognitive Impairment without Dementia in Older Mexican Americans: Results from the Sacramento Area Latino Study on Aging. American Journal of Epidemiology, 173(10), 1148-1158. PMCID: PMC3121319
AbstractThere have been few investigations of the link between changes in life-course socioeconomic position (SEP) and cognitive decline or incidence of dementia. The authors examined the impact of changes in life-course SEP on incidence of dementia and cognitive impairment but not dementia (CIND) over a decade of follow-up. Participants of Mexican origin (n = 1,789) were members of the Sacramento Area Latino Study on Aging cohort. Incidence of dementia/CIND was ascertained by using standard diagnostic criteria. SEP indicators at 3 life stages (childhood, adulthood, and midlife) were used to derive a measure of cumulative SEP (range, 0 to 8) and SEP mobility. Nearly 24% of the sample maintained a low SEP throughout life. Hazard ratios and 95% confidence intervals were computed from Cox proportional hazards regression models. In fully adjusted models, participants with a continuously high SEP had lower hazard ratios for dementia/CIND compared with those with a continuously low SEP at all 3 life stages (hazard ratio = 0.49, 95% confidence interval: 0.24, 0.98; P = 0.04). In age-adjusted models, participants experienced a 16% greater hazard of dementia/CIND with every 1-unit increase in cumulative SEP disadvantage across the life course (hazard ratio = 1.16, 95% confidence interval: 1.01, 1.33; P = 0.04). Early exposures to social disadvantage may increase the risk of late-life dementia.
Reference TypeJournal Article
Journal TitleAmerican Journal of Epidemiology
Author(s)Zeki Al Hazzouri, Adina
Haan, Mary N.
Kalbfleisch, John D.
Lisabeth, Lynda D.
Aiello, Allison E.