CitationAiello, Allison E.; Dowd, Jennifer Beam; Jayabalasingham, Bamini; Feinstein, Lydia; Uddin, Monica; Simanek, Amanda M.; Cheng, Caroline; Galea, Sandro; Wildman, Derek E.; & Koenen, Karestan C., et al. (2016). PTSD Is Associated with an Increase in Aged T Cell Phenotypes in Adults Living in Detroit. Psychoneuroendocrinology, 67, 133-141. PMCID: PMC4826331
AbstractBACKGROUND: Psychosocial stress is thought to play a key role in the acceleration of immunological aging. This study investigated the relationship between lifetime and past-year history of post-traumatic stress disorder (PTSD) and the distribution of T cell phenotypes thought to be characteristic of immunological aging.
METHODS: Data were from 85 individuals who participated in the community-based Detroit Neighborhood Health Study. Immune markers assessed included the CD4:CD8 ratio, the ratio of late-differentiated effector (CCR7-CD45RA+CD27-CD28-) to naive (CCR7+CD45RA+CD27+CD28+) T cells, the percentage of KLRG1-expressing cells, and the percentage of CD57-expressing cells.
RESULTS: In models adjusted for age, gender, race/ethnicity, education, smoking status, and medication use, we found that past-year PTSD was associated with statistically significant differences in the CD8+ T cell population, including a higher ratio of late-differentiated effector to naive T cells, a higher percentage of KLRG1+ cells, and a higher percentage of CD57+ cells. The percentage of CD57+ cells in the CD4 subset was also significantly higher and the CD4:CD8 ratio significantly lower among individuals who had experienced past-year PTSD. Lifetime PTSD was also associated with differences in several parameters of immune aging.
CONCLUSIONS: PTSD is associated with an aged immune phenotype and should be evaluated as a potential catalyzer of accelerated immunological aging in future studies.
Reference TypeJournal Article
Author(s)Aiello, Allison E.
Dowd, Jennifer Beam
Simanek, Amanda M.
Wildman, Derek E.
Koenen, Karestan C.