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Common Genetic Variation near the Connexin-43 Gene Is Associated with Resting Heart Rate in African Americans: A Genome-Wide Association Study of 13,372 Participants

Citation

Deo, Rajat; Nalls, Michael A.; Avery, Christy L.; Smith, J. Gustav; Evans, Daniel S.; Keller, Margaux F.; Butler, Anne M.; Buxbaum, Sarah G.; Li, Guo; & Quibrera, P. Miguel, et al. (2013). Common Genetic Variation near the Connexin-43 Gene Is Associated with Resting Heart Rate in African Americans: A Genome-Wide Association Study of 13,372 Participants. Heart Rhythm, 10(3), 401-408. PMCID: PMC3718037

Abstract

BACKGROUND: Genome-wide association studies have identified several genetic loci associated with variation in resting heart rate in European and Asian populations. No study has evaluated genetic variants associated with heart rate in African Americans.
OBJECTIVE: To identify novel genetic variants associated with resting heart rate in African Americans.
METHODS: Ten cohort studies participating in the Candidate-gene Association Resource and Continental Origins and Genetic Epidemiology Network consortia performed genome-wide genotyping of single nucleotide polymorphisms (SNPs) and imputed 2,954,965 SNPs using HapMap YRI and CEU panels in 13,372 participants of African ancestry. Each study measured the RR interval (ms) from 10-second resting 12-lead electrocardiograms and estimated RR-SNP associations using covariate-adjusted linear regression. Random-effects meta-analysis was used to combine cohort-specific measures of association and identify genome-wide significant loci (PRESULTS: Fourteen SNPs on chromosome 6q22 exceeded the genome-wide significance threshold. The most significant association was for rs9320841 (+13 ms per minor allele; P = 4.98x10(-15)). This SNP was approximately 350 kb downstream of

URL

http://dx.doi.org/10.1016/j.hrthm.2012.11.014

Reference Type

Journal Article

Year Published

2013

Journal Title

Heart Rhythm

Author(s)

Deo, Rajat
Nalls, Michael A.
Avery, Christy L.
Smith, J. Gustav
Evans, Daniel S.
Keller, Margaux F.
Butler, Anne M.
Buxbaum, Sarah G.
Li, Guo
Quibrera, P. Miguel
Smith, Erin N.
Tanaka, Toshiko
Akylbekova, Ermeg L.
Alonso, Alvaro
Arking, Dan E.
Benjamin, Emelia J.
Berenson, Gerald S.
Bis, Joshua C.
Chen, Lin Yee
Chen, Wei
Cummings, Steven R.
Ellinor, Patrick T.
Evans, Michael K.
Ferrucci, Luigi
Fox, Ervin R.
Heckbert, Susan R.
Heiss, Gerardo M.
Hsueh, Wen-Chi
Kerr, Kathleen F.
Limacher, Marian C.
Liu, Yongmei
Lubitz, Steven A.
Magnani, Jared W.
Mehra, Reena
Marcus, Gregory M.
Murray, Sarah S.
Newman, Anne B.
Njajou, Omer T.
North, Kari E.
Paltoo, Dina N.
Psaty, Bruce M.
Redline, Susan S.
Reiner, Alexander P.
Robinson, Jennifer G.
Rotter, Jerome I.
Samdarshi, Tandaw E.
Schnabel, Renate B.
Schork, Nicholas J.
Singleton, Andrew B.
Siscovick, David S.
Soliman, Elsayed Z.
Sotoodehnia, Nona
Srinivasan, Sathanur R.
Taylor, Herman A., Jr.
Trevisan, Maurizio
Zhang, Zhu-Ming
Zonderman, Alan B.
Newton-Cheh, Christopher H.
Whitsel, Eric A.

PMCID

PMC3718037