Citation
Chen, Chunling; Bharucha, Vandana; Chen, Yuan; Westenbroek, Ruth E.; Brown, Angus; Malhotra, Jyoti Dhar; Jones, Dorothy; Avery, Christy L.; Gillespie, Patrick J., III; & Kazen-Gillespie, Kristin A., et al. (2002). Reduced Sodium Channel Density, Altered Voltage Dependence of Inactivation, and Increased Susceptibility to Seizures in Mice Lacking Sodium Channel Beta 2-Subunits. Proceedings of the National Academy of Sciences of the United States of America, 99(26), 17072-17077. PMCID: PMC139271Abstract
Sodium channel beta-subunits modulate channel gating, assembly, and cell surface expression in heterologous cell systems. We generated beta2(-/-) mice to investigate the role of beta2 in control of sodium channel density, localization, and function in neuronsURL
http://dx.doi.org/10.1073/pnas.212638099Reference Type
Journal ArticleYear Published
2002Journal Title
Proceedings of the National Academy of Sciences of the United States of AmericaAuthor(s)
Chen, ChunlingBharucha, Vandana
Chen, Yuan
Westenbroek, Ruth E.
Brown, Angus
Malhotra, Jyoti Dhar
Jones, Dorothy
Avery, Christy L.
Gillespie, Patrick J., III
Kazen-Gillespie, Kristin A.
Kazarinova-Noyes, Katie
Shrager, Peter G.
Saunders, Thomas L.
Macdonald, Robert L.
Ransom, Bruce R.
Scheuer, Todd
Catterall, William A.
Isom, Lori L.