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Reduced Sodium Channel Density, Altered Voltage Dependence of Inactivation, and Increased Susceptibility to Seizures in Mice Lacking Sodium Channel Beta 2-Subunits

Citation

Chen, Chunling; Bharucha, Vandana; Chen, Yuan; Westenbroek, Ruth E.; Brown, Angus; Malhotra, Jyoti Dhar; Jones, Dorothy; Avery, Christy L.; Gillespie, Patrick J., III; & Kazen-Gillespie, Kristin A., et al. (2002). Reduced Sodium Channel Density, Altered Voltage Dependence of Inactivation, and Increased Susceptibility to Seizures in Mice Lacking Sodium Channel Beta 2-Subunits. Proceedings of the National Academy of Sciences of the United States of America, 99(26), 17072-17077. PMCID: PMC139271

Abstract

Sodium channel beta-subunits modulate channel gating, assembly, and cell surface expression in heterologous cell systems. We generated beta2(-/-) mice to investigate the role of beta2 in control of sodium channel density, localization, and function in neurons

URL

http://dx.doi.org/10.1073/pnas.212638099

Reference Type

Journal Article

Year Published

2002

Journal Title

Proceedings of the National Academy of Sciences of the United States of America

Author(s)

Chen, Chunling
Bharucha, Vandana
Chen, Yuan
Westenbroek, Ruth E.
Brown, Angus
Malhotra, Jyoti Dhar
Jones, Dorothy
Avery, Christy L.
Gillespie, Patrick J., III
Kazen-Gillespie, Kristin A.
Kazarinova-Noyes, Katie
Shrager, Peter G.
Saunders, Thomas L.
Macdonald, Robert L.
Ransom, Bruce R.
Scheuer, Todd
Catterall, William A.
Isom, Lori L.

PMCID

PMC139271