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The Broader Autism Phenotype in Mothers Is Associated with Increased Discordance between Maternal-Reported and Clinician-Observed Instruments That Measure Child Autism Spectrum Disorder

Citation

Rubenstein, Eric M.; Pretzel, Rebecca E.; Windham, Gayle C.; Schieve, Laura A.; Wiggins, Lisa D.; DiGuiseppi, Carolyn; Olshan, Andrew F.; Howard, Annie Green; Pence, Brian W.; & Young, Lisa, et al. (2017). The Broader Autism Phenotype in Mothers Is Associated with Increased Discordance between Maternal-Reported and Clinician-Observed Instruments That Measure Child Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 47(10), 3253-3266. PMCID: PMC5728366

Abstract

Autism spectrum disorder (ASD) diagnosis relies on parent-reported and clinician-observed instruments. Sometimes, results between these instruments disagree. The broader autism phenotype (BAP) in parent-reporters may be associated with discordance. Study to Explore Early Development data (N = 712) were used to address whether mothers with BAP and children with ASD or non-ASD developmental disabilities were more likely than mothers without BAP to 'over-' or 'under-report' child ASD on ASD screeners or interviews compared with clinician observation or overall impression. Maternal BAP was associated with a child meeting thresholds on a maternal-reported screener or maternal interview when clinician ASD instruments or impressions did not (risk ratios: 1.30 to 2.85). Evidence suggests acknowledging and accounting for reporting discordances may be important when diagnosing ASD.

URL

http://dx.doi.org/10.1007/s10803-017-3248-4

Reference Type

Journal Article

Year Published

2017

Journal Title

Journal of Autism and Developmental Disorders

Author(s)

Rubenstein, Eric M.
Pretzel, Rebecca E.
Windham, Gayle C.
Schieve, Laura A.
Wiggins, Lisa D.
DiGuiseppi, Carolyn
Olshan, Andrew F.
Howard, Annie Green
Pence, Brian W.
Young, Lisa
Daniels, Julie L.

PMCID

PMC5728366