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Association of Chorioamnionitis and Its Duration with Neonatal Morbidity and Mortality


Venkatesh, Kartik K.; Jackson, Wesley; Hughes, Brenna L.; Laughon, Matthew M.; Thorp, John M., Jr.; & Stamilio, David M. (2019). Association of Chorioamnionitis and Its Duration with Neonatal Morbidity and Mortality. Journal of Perinatology, 39(5), 673-682.


OBJECTIVE: To investigate the association of chorioamnionitis, and secondarily its duration, on neonatal adverse outcomes for infants born <34 weeks vs. >/=34 weeks.
STUDY DESIGN: A secondary analyss from the observational U.S. Consortium on Safe Labor Study. The exposure was chorioamnionitis, and secondarily, its estimated duration. The composite outcome included pneumonia, seizure, necrotizing enterocolitis, sepsis, periventricular/intraventricular/cerebral hemorrhage, mechanical ventilation, and neonatal death. Multivariable logistic regression with generalized estimating equations was used, stratified by gestational age at delivery.
RESULTS: Among 221,274 deliveries, the odds of the neonatal adverse outcome <34 weeks was 2-fold higher among infants exposed to chorioamnionitis vs. those who were not (62.0 vs. 47.7%; AOR: 1.86; 95%CI: 1.25-2.75), and was ~3.5-fold higher >/=34 weeks (9.2 vs. 2.5%; AOR: 3.34; 95% CI: 2.35-4.76). The estimated duration of chorioamnionitis did not change the above associations.
CONCLUSIONS: Chorioamnionitis was associated with an approximately 2- and 3.5-fold increased odds of neonatal adverse outcomes <34 and >/=34 weeks, respectively, regardless of its estimated duration.


Reference Type

Journal Article

Year Published


Journal Title

Journal of Perinatology

Series Title

KK Venkatesh et al. J Perinatol 39 (5), 761. May 2019. PMID 30842550.


Venkatesh, Kartik K.
Jackson, Wesley
Hughes, Brenna L.
Laughon, Matthew M.
Thorp, John M., Jr.
Stamilio, David M.