Longitudinal Interrelationship between HIV Viral Suppression, Maternal Weight Change, Breastfeeding, and Length in HIV-Exposed and -Uninfected Infants Participating in the Kabeho Study in Kigali, Rwanda

Citation

Lane, Charlotte E.; Adair, Linda S.; Bobrow, Emily A.; Ndayisaba, Gilles F.; Asiimwe, Anita; & Mugwaneza, Placidie (2021). Longitudinal Interrelationship between HIV Viral Suppression, Maternal Weight Change, Breastfeeding, and Length in HIV-Exposed and -Uninfected Infants Participating in the Kabeho Study in Kigali, Rwanda. Annals of Epidemiology, 53, 1-6.e1. PMCID: PMC7747133

Abstract

PURPOSE: The health of infants which are HIV-exposed and -uninfected (HEU) is a major public health concern as HIV becomes a chronic condition. We investigate the interrelationship between maternal viral suppression, maternal weight status, breastfeeding, and infants which are HEU.
METHODS: The Kabeho study followed 502 HEU infants in Kigali, Rwanda for 24 months from 2013-2014. We use a structural equation modeling approach to investigate the dynamic relationships between viral suppression, maternal weight change, breastfeeding, and infant length-for-age z-score (LAZ) as defined by the WHO.
RESULTS: Older mothers are more likely to be virally suppressed and to breastfeed. Viral suppression and the mother being on antiretroviral treatment for longer were related to lower infant LAZ at three months. A more positive maternal weight change was related to higher infant LAZ at the end of each period. At 12 months, a higher infant LAZ was related to increased probability of continued breastfeeding. At 18 months, continued breastfeeding was related to lower LAZ, and food shortages were related to higher LAZ.
CONCLUSION: There is a complex interrelationship between viral suppression, maternal weight change, breastfeeding, and infant LAZ. These relationships demonstrate the link between maternal and infant health in the context of HIV.

URL

http://dx.doi.org/10.1016/j.annepidem.2020.08.008

Reference Type

Journal Article

Year Published

2021

Journal Title

Annals of Epidemiology

Author(s)

Lane, Charlotte E.
Adair, Linda S.
Bobrow, Emily A.
Ndayisaba, Gilles F.
Asiimwe, Anita
Mugwaneza, Placidie

PMCID

PMC7747133

Data Set/Study

Kabeho Study

Continent/Country

Rwanda

Race/Ethnicity

Women

ORCiD

Adair - 0000-0002-3670-8073
Lane, C. - 000-0002-7730-6687