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Reasons People Living with HIV Might Prefer Oral Daily Antiretroviral Therapy, Long-Acting Formulations, or Future HIV Remission Options

Citation

Dube, Karine; Campbell, Danielle; Perry, Kelly; Kanazawa, John; Saberi, Parya; Sauceda, John; Poteat, Tonia; & Evans, David (2020). Reasons People Living with HIV Might Prefer Oral Daily Antiretroviral Therapy, Long-Acting Formulations, or Future HIV Remission Options. AIDS Research and Human Retroviruses, 36(12), 1054-1058. PMCID: PMC7703233

Abstract

BACKGROUND: A growing body of research is beginning to elucidate reasons people living with HIV (PLWHIV) might prefer oral daily antiretroviral treatment (ART) compared to emerging long-acting ART (LA-ART) or HIV remission strategies under investigation. Our objective is to provide qualitative insights into the reasons why PLWHIV might prefer one of these HIV control therapies over the others.
METHODS: From May - August 2018, we implemented a semi-structured, cross-sectional survey of PLWHIV in the United States to better understand patient preferences around various HIV treatment and remission options. Using free text, respondents were asked to explain why they preferred one HIV control option over the other two. We analyzed responses to the open-ended survey questions on reasons for preferring oral daily ART versus LA-ART versus HIV remission strategies using conventional content analysis.
RESULTS: The results showed that PLWHIV preferred oral daily ART because of its familiarity and known safety and efficacy profile, while those who preferred LA-ART would value the convenience it offers. Lastly, HIV remission strategies would be preferred to avoid taking ART altogether.
CONCLUSIONS: The qualitative results provide insights into reasons why PLWHIV in the United States might prefer oral daily ART versus novel therapies. More importantly, they provide information to better align HIV virologic control strategies with end-user perspectives. To make informed choices around evolving HIV therapeutics, PLWHIV and HIV care providers would benefit from decision tools to better assess options and trade-offs. More research is needed on how best to effectively support PLWHIV and HIV care providers in shared decision-making.

URL

http://dx.doi.org/10.1089/aid.2020.0107

Reference Type

Journal Article

Article Type

Regular

Year Published

2020

Journal Title

AIDS Research and Human Retroviruses

Author(s)

Dube, Karine
Campbell, Danielle
Perry, Kelly
Kanazawa, John
Saberi, Parya
Sauceda, John
Poteat, Tonia
Evans, David

PMCID

PMC7703233

Continent/Country

United States of America

State

Nonspecific