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Projections of Incident Atherosclerotic Cardiovascular Disease and Incident Type 2 Diabetes across Evolving Statin Treatment Guidelines and Recommendations: A Modelling Study

Citation

Engeda, Joseph C.; Lhachimi, Stefan K.; Rosamond, Wayne D.; Lund, Jennifer L.; Keyserling, Thomas C.; Safford, Monika M.; Colantonio, Lisandro D.; Muntner, Paul; & Avery, Christy L. (2020). Projections of Incident Atherosclerotic Cardiovascular Disease and Incident Type 2 Diabetes across Evolving Statin Treatment Guidelines and Recommendations: A Modelling Study. PLOS Medicine, 17(8), e1003280. PMCID: PMC7449387

Abstract

BACKGROUND: Experimental and observational research has suggested the potential for increased type 2 diabetes (T2D) risk among populations taking statins for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). However, few studies have directly compared statin-associated benefits and harms or examined heterogeneity by population subgroups or assumed treatment effect. Thus, we compared ASCVD risk reduction and T2D incidence increases across 3 statin treatment guidelines or recommendations among adults without a history of ASCVD or T2D who were eligible for statin treatment initiation.

URL

http://dx.doi.org/10.1371/journal.pmed.1003280

Reference Type

Journal Article

Journal Title

PLOS Medicine

Author(s)

Engeda, Joseph C.
Lhachimi, Stefan K.
Rosamond, Wayne D.
Lund, Jennifer L.
Keyserling, Thomas C.
Safford, Monika M.
Colantonio, Lisandro D.
Muntner, Paul
Avery, Christy L.

Year Published

2020

Volume Number

17

Issue Number

8

Pages

e1003280

PMCID

PMC7449387

Reference ID

13096