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Reply to Brown et al


Hernández-Cordero, Sonia; Barquera, Simón; Rodríguez-Ramírez, Sonia; Villanueva-Borbolla, María Angeles; González de Cossio, Teresa; Rivera Dommarco, Juan; & Popkin, Barry M. (2015). Reply to Brown et al. Journal of Nutrition, 145(5), 1029-1030.


The presentation of a secondary analysis is somewhat common and, as the articles we cited note, can be performed when handled appropriately. Eminent journals, such as The Journal of Nutrition, The New England Journal of Medicine, and Pediatrics, allow use of secondary results. Here, we will mention 2 articles by a major figure on this same topic. The first article, appearing in Pediatrics, presents a randomized controlled trial in which Ludwig's article notes that the primary outcome was not met but that baseline BMI was a significant effect modifier (4). Second, in a trial in a more recent article in The New England Journal of Medicine, the same authors noted that the 2-y core results were not significant; however, they noted that the first year of the intervention produced significant results (5). Again, these results are described in the article and are mentioned in the abstract and the study conclusion as secondary results.


Reference Type

Journal Article

Year Published


Journal Title

Journal of Nutrition


Hernández-Cordero, Sonia
Barquera, Simón
Rodríguez-Ramírez, Sonia
Villanueva-Borbolla, María Angeles
González de Cossio, Teresa
Rivera Dommarco, Juan
Popkin, Barry M.