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SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures

Citation

Barzin, Amir; Schmitz, John L.; Rosin, Samuel; Sirpal, Rameet; Almond, Martha; Robinette, Carole; Wells, Samantha; Hudgens, Michael G.; Olshan, Andrew F.; & Deen, Stephanie, et al. (2020). SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures. mBio, 11(5), e02426-20. PMCID: PMC7527736

Abstract

Characterizing the asymptomatic spread of SARS-CoV-2 is important for understanding the COVID-19 pandemic. This study was aimed at determining asymptomatic spread of SARS-CoV-2 in a suburban, Southern U.S. population during a period of state restrictions and physical distancing mandates. This is one of the first published seroprevalence studies from North Carolina and included multicenter, primary care, and emergency care facilities serving a low-density, suburban and rural population since description of the North Carolina state index case introducing the SARS-CoV-2 respiratory pathogen to this population. To estimate point seroprevalence of SARS-CoV-2 among asymptomatic individuals over time, two cohort studies were examined. The first cohort study, named ScreenNC, was comprised of outpatient clinics, and the second cohort study, named ScreenNC2, was comprised of inpatients unrelated to COVID-19. Asymptomatic infection by SARS-CoV-2 (with no clinical symptoms) was examined using an Emergency Use Authorization (EUA)-approved antibody test (Abbott) for the presence of SARS-CoV-2 IgG. This assay as performed under CLIA had a reported specificity/sensitivity of 100%/99.6%. ScreenNC identified 24 out of 2,973 (0.8%) positive individuals among asymptomatic participants accessing health care during 28 April to 19 June 2020, which was increasing over time. A separate cohort, ScreenNC2, sampled from 3 March to 4 June 2020, identified 10 out of 1,449 (0.7%) positive participants.

URL

http://dx.doi.org/10.1128/mBio.02426-20

Reference Type

Journal Article

Journal Title

mBio

Author(s)

Barzin, Amir
Schmitz, John L.
Rosin, Samuel
Sirpal, Rameet
Almond, Martha
Robinette, Carole
Wells, Samantha
Hudgens, Michael G.
Olshan, Andrew F.
Deen, Stephanie
Krejci, Patrick
Quackenbush, Eugenia
Chronowski, Kevin
Cornaby, Caleb
Goins, Janette
Butler, Linda
Aucoin, Julia
Boyer, Kim
Faulk, Janet
Alston-Johnson, Devena
Page, Cristen
Zhou, Yijun
Fiscus, Lynne
Damania, Blossom
Dittmer, Dirk P.
Peden, David B.

Year Published

2020

Volume Number

11

Issue Number

5

Pages

e02426-20

PMCID

PMC7527736

Reference ID

13238