Epidemiology of Basal-Like and Luminal Breast Cancers among Black Women in the AMBER Consortium

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Citation

Benefield, Halei C.; Zirpoli, Gary R.; Allott, Emma H.; Shan, Yue; Hurson, Amber N.; Omilian, Angela; Khoury, Thaer; Hong, Chi-Chen; Olshan, Andrew F.; & Bethea, Traci N., et al. (2021). Epidemiology of Basal-Like and Luminal Breast Cancers among Black Women in the AMBER Consortium. Cancer Epidemiology, Biomarkers & Prevention, 30(1), 71-79. PMCID: PMC8935955

Abstract

BACKGROUND: Evidence suggests etiologic heterogeneity among breast cancer subtypes. Previous studies with six-marker immunohistochemical classification of intrinsic subtypes included small numbers of black women.
METHODS: Using centralized laboratory results for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), proliferation marker Ki-67, epidermal growth factor receptor (EGFR), and cytokeratin (CK)5/6, we estimated case-only and case-control odds ratios (ORs) for established breast cancer risk factors among cases (n=2,354) and controls (n =2,932) in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium. ORs were estimated by ER status and intrinsic subtype using adjusted logistic regression.
RESULTS: Case-only analyses by ER status showed etiologic heterogeneity by age at menarche, parity (versus nulliparity), and age at first birth. In case-control analyses for intrinsic subtype, increased body mass index (BMI) and waist-to-hip (WHR) ratio were associated with increased risk of luminal A subtype, while older age at menarche and parity, regardless of breastfeeding, were associated with reduced risk. For basal-like cancers, parity without breastfeeding and increasing WHR were associated with increased risk, whereas breastfeeding and age

URL

http://dx.doi.org/10.1158/1055-9965.Epi-20-0556

Reference Type

Journal Article

Year Published

2021

Journal Title

Cancer Epidemiology, Biomarkers & Prevention

Author(s)

Benefield, Halei C.
Zirpoli, Gary R.
Allott, Emma H.
Shan, Yue
Hurson, Amber N.
Omilian, Angela
Khoury, Thaer
Hong, Chi-Chen
Olshan, Andrew F.
Bethea, Traci N.
Bandera, Elisa V.
Palmer, Julie R.
Ambrosone, Christine B.
Troester, Melissa A.

Article Type

Regular

PMCID

PMC8935955

Data Set/Study

African American Breast Cancer Epidemiology and Risk (AMBER) Consortium
Carolina Breast Cancer Study (CBCS)
Black Women’s Health Study
Women's Circle of Health Study
Multiethnic Cohort (MEC) Study

Continent/Country

United States of America

State

Nonspecific

Race/Ethnicity

Black

Sex/Gender

Women

ORCiD

Olshan - 0000-0001-9115-5128