Citation
Benefield, Halei C.; Reeder-Hayes, Katherine E.; Nichols, Hazel B.; Calhoun, Benjamin C.; Love, Michael I.; Kirk, Erin L.; Geradts, Joseph; Hoadley, Katherine A.; Cole, Stephen R.; & Earp, H. Shelton, et al. (2021). Outcomes of Hormone-Receptor Positive, HER2-Negative Breast Cancers by Race and Tumor Biological Features. JNCI Cancer Spectrum, 5(1), pkaa072. PMCID: PMC7791616Abstract
Background: Black women have higher hormone receptor positive (HR+) breast cancer mortality than White women. Early recurrence rates differ by race, but little is known about genomic predictors of early recurrence among HR+ women.Methods: Using data from the Carolina Breast Cancer Study (phase III, 2008-2013), we estimated associations between race and recurrence among nonmetastatic HR+/HER2-negative tumors, overall and by PAM50 Risk of Recurrence score, PAM50 intrinsic subtype, and tumor grade using survival curves and Cox models standardized for age and stage. Relative frequency differences (RFD) were estimated using multivariable linear regression. To assess intervention opportunities, we evaluated treatment patterns by race among patients with high-risk disease.
Results: Black women had higher recurrence risk relative to White women (crude hazard ratio = 1.81, 95% confidence interval [CI] = 1.34 to 2.46), which remained elevated after standardizing for clinical covariates (hazard ratio = 1.42, 95% CI = 1.05 to 1.93). Racial disparities were most pronounced among those with high PAM50 Risk of Recurrence score (5-year standardized recurrence risk = 18.9%, 95% CI = 8.6% to 29.1% in Black women vs 12.5%, 95% CI = 2.0% to 23.0% in White women) and high grade (5-year standardized recurrence risk = 16.6%, 95% CI = 11.7% to 21.5% in Black women vs 12.0%, 95% CI = 7.3% to 16.7% in White women). However, Black women with high-grade tumors were statistically significantly less likely to initiate endocrine therapy (RFD =
URL
https://doi.org/10.1093/jncics/pkaa072Reference Type
Journal ArticleYear Published
2021Journal Title
JNCI Cancer SpectrumAuthor(s)
Benefield, Halei C.Reeder-Hayes, Katherine E.
Nichols, Hazel B.
Calhoun, Benjamin C.
Love, Michael I.
Kirk, Erin L.
Geradts, Joseph
Hoadley, Katherine A.
Cole, Stephen R.
Earp, H. Shelton
Olshan, Andrew F.
Carey, Lisa A.
Perou, Charles M.
Troester, Melissa A.