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Genome Studies Must Account for History-Response


Ganna, Andrea; Verweij, Karin J. H.; Nivard, Michel G.; Maier, Robert; Wedow, Robbee; Busch, Alexander S.; Abdellaoui, Abdel; Guo, Shengru; Sathirapongsasuti, J. Fah; & 23andMe Research Team,, et al. (2019). Genome Studies Must Account for History-Response. Science, 366(6472), 1461-1462.


Our genome-wide association study (GWAS) on same-sex sexual behavior, which used data from the UK Biobank, was reviewed and approved by the UK Biobank Access Sub-Committee. We also sought stakeholder input from allies and advocates for the LGBTQIA+ community, as has been done in the past. Despite these efforts, Holm and Ploug contend that broad biobank consent is insufficient. They argue that our study only tenuously qualifies as “health-related” and thus stretches the bounds of the participants’ consent.


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Ganna, Andrea
Verweij, Karin J. H.
Nivard, Michel G.
Maier, Robert
Wedow, Robbee
Busch, Alexander S.
Abdellaoui, Abdel
Guo, Shengru
Sathirapongsasuti, J. Fah
23andMe Research Team,
Lichtenstein, Paul
Lundström, Sebastian
Långström, Niklas
Auton, Adam
Harris, Kathleen Mullan
Beecham, Gary W.
Martin, Eden R.
Sanders, Alan R.
Perry, John R. B.
Neale, Benjamin M.
Zietsch, Brendan P.