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Nifedipine Enhances the Cardiac Toxicity of Magnesium Sulfate in the Isolated Perfused Sprague-Dawley Rat Heart

Citation

Thorp, John M., Jr.; Spielman, F. .J.; Valea, Fidel A.; Payne, F. G.; Mueller, R. A.; & Cefalo, Robert C. (1990). Nifedipine Enhances the Cardiac Toxicity of Magnesium Sulfate in the Isolated Perfused Sprague-Dawley Rat Heart. American Journal of Obstetrics & Gynecology, 163(2), 655-656.

Abstract

Magnesium sulfate is commonly used in tocolytic regimens and as prophylaxis against seizures. Nifedipine may be used simultaneously in either situation. With the isolated perfused rat heart model (Sprague-Dawley rats), we investigated the effects of these agents on cardiac function. Whereas each agent alone depressed cardiac performance, the two drugs together had maximal depressive effects on the heart.

URL

http://dx.doi.org/10.1016/0002-9378(90)91218-2

Reference Type

Journal Article

Year Published

1990

Journal Title

American Journal of Obstetrics & Gynecology

Author(s)

Thorp, John M., Jr.
Spielman, F. .J.
Valea, Fidel A.
Payne, F. G.
Mueller, R. A.
Cefalo, Robert C.