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Treatment of Persistent Postpartum HELLP Syndrome with Plasmapheresis


Katz, Vern L.; Watson, William J.; Thorp, John M., Jr.; Hansen, Wendy; & Bowes, Watson A., Jr. (1992). Treatment of Persistent Postpartum HELLP Syndrome with Plasmapheresis. American Journal of Perinatology, 9(2), 120-122.


Thrombocytopenia, associated with microangiopathic disease, is one characteristic of severe preeclampsia. Thrombocytopenia and intravascular hemolysis usually resolve by postpartum days 4 to 5. When thrombocytopenia secondary to microangiopathic disease persists, plasmapheresis may be used to arrest and reverse the process. Three patients over a 24-month period were successfully treated with plasma exchange with fresh frozen plasma. Several investigators who have cared for patients with persistent thrombocytopenia associated with preeclampsia have concluded that early plasmapheresis may be useful therapy. Plasma exchange should also be considered as a therapeutic option when clinical deterioration occurs due to microangiopathic disease.


Reference Type

Journal Article

Year Published


Journal Title

American Journal of Perinatology


Katz, Vern L.
Watson, William J.
Thorp, John M., Jr.
Hansen, Wendy
Bowes, Watson A., Jr.