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Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study


Thatipelli, Sneha; Kershaw, Kiarri N.; Colangelo, Laura A.; Gordon-Larsen, Penny; Jacobs, David R., Jr.; Dransfield, Mark T.; Meza, Daniel; Rosenberg, Sharon R.; Washko, George R.; & Parekh, Trisha M., et al. (Online ahead of print). Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study. American Journal of Medicine.


PURPOSE: There are limited data on the relationship between neighborhood level factors and their association with lung health independent of individual socioeconomic status. We soughto determine whether baseline neighborhood level socioeconomic deprivation in young adults is associated with greater 20-year decline in lung function and higher risk of future lung disease, independent of baseline individual income, education, and smoking status.
METHODS: This multi-center population-based cohort study included 2689 CARDIA participants for whom neighborhood deprivation was determined at year 10 (baseline for study) and who had complete lung function measurements at years 10 and 30. Baseline neighborhood deprivation was defined using 1990 Census blocks as a combination of four factors involving median household income, poverty level, and educational achievement. The outcomes were decline in lung function over 20 years (year 10 to 30) and odds of emphysema (year 25).
RESULTS: In multivariable regression models, greater baseline neighborhood deprivation was associated with greater decline in lung function (-2.34 mL/year excess annual decline in FEV(1) in the highest versus lowest deprivation quartile (p=0.014)). Furthermore, baseline neighborhood deprivation was independently associated with greater odds of emphysema (OR 2.99, 95% CI 1.42-6.30).
CONCLUSIONS: Residence in neighborhoods with greater socioeconomic deprivation in young adulthood, independent of individual income and smoking, is associated with greater 20-year decline in FEV(1) and higher risk of future emphysema.


Reference Type

Journal Article

Year Published

Online ahead of print

Journal Title

American Journal of Medicine


Thatipelli, Sneha
Kershaw, Kiarri N.
Colangelo, Laura A.
Gordon-Larsen, Penny
Jacobs, David R., Jr.
Dransfield, Mark T.
Meza, Daniel
Rosenberg, Sharon R.
Washko, George R.
Parekh, Trisha M.
Carnethon, Mercedes R.
Kalhan, Ravi

Article Type


Data Set/Study

Coronary Artery Risk Development in Young Adults (CARDIA)


United States of America




Gordon-Larsen - 0000-0001-5322-4188