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Tielbeek, Jorim J.; Uffelmann, Emil; Williams, Benjamin S.; Colodro-Conde, Lucía; Gagnon, Éloi; Mallard, Travis T.; Levitt, Brandt; Jansen, Philip R.; Johansson, Ada; & Sallis, Hannah, et al. (Preprint). Uncovering the Genetic Architecture of Broad Antisocial Behavior through a Genome-Wide Association Study Meta-analysis. BioRxiv.


Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants robustly associated with the trait have not been identified. The present study by the Broad Antisocial Behavior Consortium (BroadABC) meta-analyzed data from 28 discovery samples (N = 85,359) and five independent replication samples (N = 8,058) with genotypic data and broad measures of ASB. We identified the first significant genetic associations with broad ASB, involving common intronic variants in the forkhead box protein P2 (FOXP2) gene (lead SNP rs12536335, P = 6.32 x 10-10). Furthermore, we observed intronic variation in Foxp2 and one of its targets (Cntnap2) distinguishing a mouse model of pathological aggression (BALB/cJ strain) from controls (BALB/cByJ strain). The SNP-based heritability of ASB was 8.4% (s.e.= 1.2%). Polygenic-risk-score (PRS) analyses in independent samples revealed that the genetic risk for ASB was associated with several antisocial outcomes across the lifespan, including diagnosis of conduct disorder, official criminal convictions, and trajectories of antisocial development. We found substantial genetic correlations of ASB with mental health (depression rg=0.63, insomnia rg = 0.47), physical health (overweight rg = 0.19, waist-to-hip ratio rg = 0.32), smoking (rg=0.54), cognitive ability (intelligence rg=


Reference Type

Journal Article

Year Published


Journal Title



Tielbeek, Jorim J.
Uffelmann, Emil
Williams, Benjamin S.
Colodro-Conde, Lucía
Gagnon, Éloi
Mallard, Travis T.
Levitt, Brandt
Jansen, Philip R.
Johansson, Ada
Sallis, Hannah
Pistis, Giorgio
Saunders, Gretchen R.B.
Allegrini, Andrea G.
Rimfeld, Kaili
Konte, Bettina
Klein, Marieke
Hartmann, Annette M.
Salvatore, Jessica E.
Nolte, Ilja M.
Demontis, Ditte
Malmberg, Anni
Burt, S. Alexandra
Savage, Jeanne
Sugden, Karen
Poulton, Richie
Harris, Kathleen Mullan
Vrieze, Scott
McGue, Matt
Iacono, William G.
Mota, Nina Roth
Mill, Jonathan
Viana, Joana F.
Mitchell, Brittany L.
Morosoli, Jose J.
Andlauer, Till
Ouellet-Morin, Isabelle
Tremblay, Richard E.
Côté, Sylvana
Gouin, Jean-Philippe
Brendgen, Mara
Dionne, Ginette
Vitaro, Frank
Lupton, Michelle K.
Martin, Nicholas G.
COGA Consortium
Spit for Science Working Group
Castelao, Enrique
Räikkönen, Katri
Eriksson, Johan
Lahti, Jari
Hartman, Catharina A
Oldehinkel, Albertine J.
Snieder, Harold
Liu, Hexuan
Preisig, Martin
Whipp, Alyce
Vuoksimaa, Eero
Lu, Yi
Jern, Patrick
Rujescu, Dan
Giegling, Ina
Palviainen, Teemu
Kaprio, Jaakko
Harden, Kathryn Paige
Munafò, Marcus R.
Morneau-Vaillancourt, Geneviève
Plomin, Robert
Viding, Essi
Boutwell, Brian
Aliev, Fazil
Dick, Danielle
Popma, Arne
Faraone, Stephen V.
Børglum, Anders
Medland, Sarah E.
Franke, Barbara
Boivin, Michel
Pingault, Jean-Baptiste
Glennon, Jeffrey C.
Barnes, James C.
Fisher, Simon E.
Moffitt, Terrie E.
Caspi, Avshalom
Polderman, Tinca J. C.
Posthuma, Danielle

Article Type


Data Set/Study

Broad Antisocial Behavior Consortium (BroadABC)


Harris, KM - 0000-0001-9757-1026