Gestational Organophosphate Ester Exposure and Preschool Attention-Deficit/Hyperactivity Disorder in the Norwegian Mother, Father, and Child Cohort Study

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Citation

Hall, Amber M.; Ramos, Amanda M.; Drover, Samantha S. M.; Choi, Giehae; Keil, Alexander P.; Richardson, David B.; Martin, Chantel L.; Olshan, Andrew F.; Villanger, Gro D.; & Reichborn-Kjennerud, Ted, et al. (2023). Gestational Organophosphate Ester Exposure and Preschool Attention-Deficit/Hyperactivity Disorder in the Norwegian Mother, Father, and Child Cohort Study. International Journal of Hygiene and Environmental Health, 248, 114078. PMCID: PMC9898152

Abstract

BACKGROUND: Attention-deficit/hyperactivity-disorder (ADHD) is a leading neurodevelopmental disorder in children worldwide; however, few modifiable risk factors have been identified. Organophosphate esters (OPEs) are ubiquitous chemical compounds that are increasingly prevalent as a replacement for other regulated chemicals. Current research has linked OPEs to neurodevelopmental deficits. The purpose of this study was to assess gestational OPE exposure on clinically-assessed ADHD in children at age 3 years.
METHODS: In this nested case-control study within the Norwegian Mother, Father, and Child Cohort study, we evaluated the impact of OPE exposure at 17 weeks' gestation on preschool-age ADHD. Between 2007 and 2011, 260 ADHD cases were identified using the Preschool Age Psychiatric Assessment and compared to a birth-year-stratified control group of 549 children. We categorized bis(2-butoxyethyl) phosphate (BBOEP) and bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) as values < limit of detection (LOD) (BBOEP N = 386, BDCIPP N = 632),

URL

http://dx.doi.org/10.1016/j.ijheh.2022.114078

Reference Type

Journal Article

Year Published

2023

Journal Title

International Journal of Hygiene and Environmental Health

Author(s)

Hall, Amber M.
Ramos, Amanda M.
Drover, Samantha S. M.
Choi, Giehae
Keil, Alexander P.
Richardson, David B.
Martin, Chantel L.
Olshan, Andrew F.
Villanger, Gro D.
Reichborn-Kjennerud, Ted
Zeiner, Pål
Øvergaard, Kristin R.
Sakhi, Amrit K.
Thomsen, Cathrine
Aase, Heidi
Engel, Stephanie M.

Article Type

Regular

PMCID

PMC9898152

Data Set/Study

Norwegian Mother, Father and Child Birth Cohort Study

Continent/Country

Norway

ORCiD

Olshan - 0000-0001-9115-5128
Martin, C. - 0000-0003-1907-0810